[9] Tranmere 2-0 Colchester [18] 2021-10-08 18:45
Stadium: Prenton Park Round: 11
Referee: James Oldham Home Manager: Micky Mellon Away Manager: Hayden Mullins
Head to Head
| England League 2 | 2021/05/08 14:00 | Tranmere v Colchester | D | 0-0 |
| England League 2 | 2021/03/23 19:00 | Colchester v Tranmere | D | 2-2 |
| England League 2 | 2019/03/23 15:00 | Colchester v Tranmere | W | 0-2 |
| England League 2 | 2018/09/08 14:00 | Tranmere v Colchester | D | 1-1 |
Home History
| England EFL Trophy | 2021/10/05 18:00 | Salford City v Tranmere | W | 0-2 |
| England League 2 | 2021/10/02 14:00 | Tranmere v Crawley Town | W | 2-1 |
| England League 2 | 2021/09/25 14:00 | Forest Green v Tranmere | D | 0-0 |
| England League 2 | 2021/09/18 14:00 | Tranmere v Salford City | W | 2-0 |
| England EFL Trophy | 2021/09/14 18:00 | Tranmere v Leeds U21 | W | 4-1 |
| England League 2 | 2021/09/11 14:00 | Rochdale v Tranmere | L | 1-0 |
| England League 2 | 2021/09/04 14:00 | Tranmere v Hartlepool | W | 1-0 |
| England League 2 | 2021/08/28 14:00 | Scunthorpe v Tranmere | L | 1-0 |
Away History
| England League 2 | 2021/10/02 14:00 | Colchester v Salford City | L | 0-2 |
| England EFL Trophy | 2021/09/28 18:30 | Colchester v West Ham U21 | W | 1-0 |
| England League 2 | 2021/09/25 14:00 | Swindon v Colchester | D | 0-0 |
| England League 2 | 2021/09/18 14:00 | Colchester v Crawley Town | L | 0-1 |
| England League 2 | 2021/09/10 18:45 | Barrow v Colchester | W | 2-3 |
| England EFL Trophy | 2021/09/07 18:30 | Colchester v Gillingham | L | 0-1 |
| England League 2 | 2021/08/27 18:45 | Rochdale v Colchester | D | 1-1 |
| England League 2 | 2021/08/21 14:00 | Oldham v Colchester | W | 1-2 |