[4] Northampton 1-0 Leyton Orient [8] 2021-11-27 15:00
Stadium: Sixfields Stadium Round: 19
Referee: Andrew Kitchen Home Manager: Jon Brady Away Manager: Kenneth Francis Jackett
Head to Head
| Club Friendly List | 2020/08/22 12:00 | Northampton v Leyton Orient | W | 1-0 |
| England League 2 | 2020/01/21 19:45 | Leyton Orient v Northampton | D | 1-1 |
| England League 2 | 2019/10/05 14:00 | Northampton v Leyton Orient | L | 0-1 |
| England League 2 | 2016/02/13 15:00 | Leyton Orient v Northampton | W | 0-4 |
| England League 2 | 2015/09/26 14:00 | Northampton v Leyton Orient | D | 1-1 |
| England EFL Trophy | 2014/11/11 19:45 | Leyton Orient v Northampton | L | 2-0 |
| Club Friendly List | 2014/07/26 14:00 | Northampton v Leyton Orient | L | 0-1 |
Home History
| England League 2 | 2021/11/23 19:45 | Northampton v Oldham | W | 2-1 |
| England League 2 | 2021/11/20 15:00 | Bradford v Northampton | D | 1-1 |
| England FA Cup | 2021/11/16 19:45 | Cambridge Utd v Northampton | L | 3-1 |
| England League 2 | 2021/11/13 15:00 | Bristol Rovers v Northampton | L | 2-1 |
| England FA Cup | 2021/11/06 15:00 | Northampton v Cambridge Utd | D | 2-2 |
| England EFL Trophy | 2021/11/02 19:00 | Northampton v Brighton U21 | L | 1-2 |
| England League 2 | 2021/10/30 13:00 | Northampton v Carlisle | W | 3-0 |
| England League 2 | 2021/10/23 14:00 | Tranmere v Northampton | W | 0-2 |
Away History
| England League 2 | 2021/11/23 19:45 | Scunthorpe v Leyton Orient | D | 1-1 |
| England League 2 | 2021/11/20 15:00 | Leyton Orient v Sutton Utd | W | 4-1 |
| England League 2 | 2021/11/13 15:00 | Rochdale v Leyton Orient | D | 2-2 |
| England EFL Trophy | 2021/11/09 19:00 | Leyton Orient v Charlton | W | 1-0 |
| England FA Cup | 2021/11/06 15:00 | Leyton Orient v Ebbsfleet United | W | 1-0 |
| England League 2 | 2021/10/30 14:00 | Leyton Orient v Hartlepool | W | 5-0 |
| England League 2 | 2021/10/23 14:00 | Stevenage v Leyton Orient | D | 0-0 |
| England League 2 | 2021/10/19 18:45 | Leyton Orient v Forest Green | D | 1-1 |