[8] Tranmere 1-0 Leyton Orient [9] 2021-12-18 15:00
Stadium: Prenton Park Round: 22
Referee: Paul Howard Home Manager: Micky Mellon Away Manager: Kenneth Francis Jackett
Head to Head
| England FA Cup | 2021/12/04 15:00 | Leyton Orient v Tranmere | L | 4-0 |
| England League 2 | 2021/02/27 15:00 | Leyton Orient v Tranmere | W | 1-3 |
| England League 2 | 2020/10/20 18:00 | Tranmere v Leyton Orient | L | 0-1 |
| England National League | 2018/02/10 15:00 | Leyton Orient v Tranmere | D | 1-1 |
| England National League | 2017/10/04 18:45 | Tranmere v Leyton Orient | W | 2-1 |
Home History
| England League 2 | 2021/12/11 15:00 | Exeter v Tranmere | W | 0-1 |
| England League 2 | 2021/12/07 19:45 | Oldham v Tranmere | W | 0-1 |
| England FA Cup | 2021/12/04 15:00 | Leyton Orient v Tranmere | L | 4-0 |
| England League 2 | 2021/11/23 19:45 | Tranmere v Bradford | W | 2-1 |
| England League 2 | 2021/11/20 15:00 | Bristol Rovers v Tranmere | D | 2-2 |
| England League 2 | 2021/11/13 15:00 | Tranmere v Sutton Utd | L | 0-1 |
| England EFL Trophy | 2021/11/09 19:00 | Tranmere v Oldham | W | 3-2 |
| England FA Cup | 2021/11/06 15:00 | Crawley Town v Tranmere | W | 0-1 |
Away History
| England League 2 | 2021/12/11 15:00 | Leyton Orient v Crawley Town | L | 1-2 |
| England League 2 | 2021/12/07 19:45 | Leyton Orient v Swindon | W | 4-1 |
| England FA Cup | 2021/12/04 15:00 | Leyton Orient v Tranmere | W | 4-0 |
| England EFL Trophy | 2021/11/30 19:00 | Leyton Orient v Milton Keynes Dons | L | 4-5 |
| England League 2 | 2021/11/27 15:00 | Northampton v Leyton Orient | L | 1-0 |
| England League 2 | 2021/11/23 19:45 | Scunthorpe v Leyton Orient | D | 1-1 |
| England League 2 | 2021/11/20 15:00 | Leyton Orient v Sutton Utd | W | 4-1 |
| England League 2 | 2021/11/13 15:00 | Rochdale v Leyton Orient | D | 2-2 |