[6] Karlsruher SC 1-3 St Pauli [4] 2021-09-25 11:30
Stadium: Wildparkstadion Round: 8
Referee: Nicolas Winter Home Manager: Christian Eichner Away Manager: Timo Schultz
Head to Head
| Germany Bundesliga II | 2021/03/06 12:00 | Karlsruher SC v St Pauli | D | 0-0 |
| Germany Bundesliga II | 2020/11/08 12:30 | St Pauli v Karlsruher SC | W | 0-3 |
| Germany Bundesliga II | 2020/05/30 11:00 | Karlsruher SC v St Pauli | D | 1-1 |
| Germany Bundesliga II | 2019/11/02 12:00 | St Pauli v Karlsruher SC | D | 2-2 |
| Europe Friendlies | 2018/07/17 16:00 | Karlsruher SC v St Pauli | W | 4-1 |
| Germany Bundesliga II | 2017/02/27 19:15 | St Pauli v Karlsruher SC | L | 5-0 |
| Germany Bundesliga II | 2016/09/18 11:30 | Karlsruher SC v St Pauli | D | 1-1 |
| Germany Bundesliga II | 2015/12/18 17:30 | St Pauli v Karlsruher SC | W | 1-2 |
Home History
| Germany Bundesliga II | 2021/09/17 16:30 | Schalke v Karlsruher SC | W | 1-2 |
| Germany Bundesliga II | 2021/09/11 11:30 | Karlsruher SC v Holstein Kiel | D | 2-2 |
| Europe Friendlies | 2021/09/02 11:00 | Mainz v Karlsruher SC | D | 0-0 |
| Germany Bundesliga II | 2021/08/27 16:30 | Nurnberg v Karlsruher SC | L | 2-1 |
| Germany Bundesliga II | 2021/08/21 11:30 | Karlsruher SC v Werder Bremen | D | 0-0 |
| Germany Bundesliga II | 2021/08/14 11:30 | Sandhausen v Karlsruher SC | D | 0-0 |
| Germany DFB Pokal | 2021/08/09 16:30 | Sportfreunde Lotte v Karlsruher SC | W | 1-4 |
| Germany Bundesliga II | 2021/07/30 16:30 | Karlsruher SC v Darmstadt | W | 3-0 |
Away History
| Germany Bundesliga II | 2021/09/19 11:30 | St Pauli v FC Ingolstadt | W | 4-1 |
| Germany Bundesliga II | 2021/09/11 11:30 | Hannover 96 v St Pauli | L | 1-0 |
| Germany Bundesliga II | 2021/08/29 11:30 | St Pauli v Jahn Regensburg | W | 2-0 |
| Germany Bundesliga II | 2021/08/21 11:30 | Paderborn v St Pauli | L | 3-1 |
| Germany Bundesliga II | 2021/08/13 16:30 | St Pauli v Hamburg | W | 3-2 |
| Germany DFB Pokal | 2021/08/07 16:30 | Magdeburg v St Pauli | W | 2-3 |
| Germany Bundesliga II | 2021/08/01 11:30 | Erzgebirge Aue v St Pauli | D | 0-0 |
| Germany Bundesliga II | 2021/07/25 11:30 | St Pauli v Holstein Kiel | W | 3-0 |