Southern Illinois 47-21 SE Missouri State 2021-09-02 23:30
Stadium: Houck Stadium Round: 1
Home Manager: Tom Matukewicz Away Manager: Nick Hill
Head to Head
| NCAAF | 2020/10/30 23:00 | SE Missouri St v SO Illinois | W | 17-20 |
| NCAAF | 2019/08/29 23:30 | SO Illinois v SE Missouri St | L | 26-44 |
| NCAAF | 2018/09/15 23:00 | SE Missouri St v SO Illinois | L | 48-44 |
| NCAAF | 2017/09/16 23:00 | SE Missouri St v SO Illinois | W | 17-35 |
Home History
| NCAAF | 2021/05/03 01:00 | SO Illinois v South Dakota State | L | 26-31 |
| NCAAF | 2021/04/24 20:00 | SO Illinois v Weber State | W | 34-31 |
| NCAAF | 2021/04/17 17:00 | SE Louisiana v SO Illinois | W | 48-55 |
| NCAAF | 2021/03/27 19:00 | SO Illinois v Missouri St | L | 27-30 |
| NCAAF | 2021/03/20 17:00 | South Dakota State v SO Illinois | L | 44-3 |
| NCAAF | 2021/03/13 18:00 | Northern Iowa v SO Illinois | W | 16-17 |
| NCAAF | 2021/03/06 17:00 | SO Illinois v Youngstown State | W | 30-22 |
| NCAAF | 2021/02/27 18:00 | North Dakota State v SO Illinois | W | 14-38 |
Away History
| NCAAF | 2021/04/11 19:30 | SE Missouri St v Tennessee State | W | 46-23 |
| NCAAF | 2021/04/03 18:00 | SE Missouri St v Tennessee Martin | W | 21-16 |
| NCAAF | 2021/03/28 19:00 | Tennessee Tech v SE Missouri St | W | 21-24 |
| NCAAF | 2021/03/21 19:00 | SE Missouri St v Jacksonville State | L | 3-21 |
| NCAAF | 2021/03/14 19:00 | Austin Peay v SE Missouri St | L | 49-42 |
| NCAAF | 2021/03/07 20:00 | Murray State v SE Missouri St | L | 24-21 |
| NCAAF | 2021/02/28 20:00 | Eastern Illinois v SE Missouri St | W | 7-47 |
| NCAAF | 2020/10/30 23:00 | SE Missouri St v SO Illinois | L | 17-20 |