[3] Bayer Leverkusen 2-2 TSG Hoffenheim [4] 2021-12-15 19:30
Stadium: BayArena Round: 16
Referee: Tobias Stieler Home Manager: Gerardo Seoane Away Manager: Sebastian Hoeness
Head to Head
| Germany Bundesliga I | 2021/04/12 18:30 | TSG Hoffenheim v Bayer Leverkusen | D | 0-0 |
| Germany Bundesliga I | 2020/12/13 17:00 | Bayer Leverkusen v TSG Hoffenheim | W | 4-1 |
| Germany Bundesliga I | 2020/02/01 14:30 | TSG Hoffenheim v Bayer Leverkusen | L | 2-1 |
| Germany Bundesliga I | 2019/08/31 13:30 | Bayer Leverkusen v TSG Hoffenheim | D | 0-0 |
| Germany Bundesliga I | 2019/03/29 19:30 | TSG Hoffenheim v Bayer Leverkusen | L | 4-1 |
| Germany Bundesliga I | 2018/11/03 14:30 | Bayer Leverkusen v TSG Hoffenheim | L | 1-4 |
| Germany Bundesliga I | 2018/01/20 14:30 | TSG Hoffenheim v Bayer Leverkusen | W | 1-4 |
| Germany Bundesliga I | 2017/08/26 13:30 | Bayer Leverkusen v TSG Hoffenheim | D | 2-2 |
Home History
| Germany Bundesliga I | 2021/12/12 16:30 | Eintracht Frankfurt v Bayer Leverkusen | L | 5-2 |
| UEFA Europa League | 2021/12/09 20:00 | Ferencvarosi TC v Bayer Leverkusen | L | 1-0 |
| Germany Bundesliga I | 2021/12/04 14:30 | Bayer Leverkusen v Greuther Furth | W | 7-1 |
| Germany Bundesliga I | 2021/11/28 16:30 | RB Leipzig v Bayer Leverkusen | W | 1-3 |
| UEFA Europa League | 2021/11/25 17:45 | Bayer Leverkusen v Celtic | W | 3-2 |
| Germany Bundesliga I | 2021/11/20 14:30 | Bayer Leverkusen v Bochum | W | 1-0 |
| Germany Bundesliga I | 2021/11/07 14:30 | Hertha Berlin v Bayer Leverkusen | D | 1-1 |
| UEFA Europa League | 2021/11/04 20:00 | Bayer Leverkusen v Real Betis | W | 4-0 |
Away History
| Germany Bundesliga I | 2021/12/11 14:30 | SC Freiburg v TSG Hoffenheim | W | 1-2 |
| Germany Bundesliga I | 2021/12/04 14:30 | TSG Hoffenheim v Eintracht Frankfurt | W | 3-2 |
| Germany Bundesliga I | 2021/11/27 14:30 | Greuther Furth v TSG Hoffenheim | W | 3-6 |
| Germany Bundesliga I | 2021/11/20 14:30 | TSG Hoffenheim v RB Leipzig | W | 2-0 |
| Germany Bundesliga I | 2021/11/06 14:30 | Bochum v TSG Hoffenheim | L | 2-0 |
| Germany Bundesliga I | 2021/10/29 18:30 | TSG Hoffenheim v Hertha Berlin | W | 2-0 |
| Germany DFB Pokal | 2021/10/26 16:30 | TSG Hoffenheim v Holstein Kiel | W | 5-1 |
| Germany Bundesliga I | 2021/10/23 13:30 | Bayern Munich v TSG Hoffenheim | L | 4-0 |