[1] River Plate 3-1 San Lorenzo [20] 2021-10-17 23:15
Stadium: Estadio Monumental Antonio Vespucio Liberti Round: 16
Referee: Facundo Tello Figueroa Home Manager: Marcelo Gallardo Away Manager: Paolo Montero
Head to Head
| Argentina Copa de la Liga Profesional | 2021/04/25 21:00 | River Plate v San Lorenzo | L | 1-2 |
| Argentina Superliga | 2019/12/09 00:45 | River Plate v San Lorenzo | L | 0-1 |
| Argentina Superliga | 2018/09/01 23:00 | San Lorenzo v River Plate | D | 1-1 |
| Argentina Superliga | 2018/05/15 00:15 | River Plate v San Lorenzo | W | 2-0 |
| Argentina Superliga | 2017/06/04 17:00 | San Lorenzo v River Plate | L | 2-1 |
| Argentina Liga Profesional | 2016/05/07 20:45 | San Lorenzo v River Plate | L | 2-1 |
| Argentina Torneo De Verano | 2016/01/27 01:10 | River Plate v San Lorenzo | W | 3-2 |
| Argentina Liga Profesional | 2015/04/05 19:00 | River Plate v San Lorenzo | W | 1-0 |
Home History
| Argentina Liga Profesional | 2021/10/09 21:00 | Banfield v River Plate | W | 0-1 |
| Argentina Liga Profesional | 2021/10/03 20:00 | River Plate v Boca Juniors | W | 2-1 |
| Argentina Liga Profesional | 2021/09/25 23:15 | Central Cordoba v River Plate | W | 1-3 |
| Argentina Liga Profesional | 2021/09/19 23:15 | River Plate v Arsenal de Sarandi | W | 1-0 |
| Argentina Liga Profesional | 2021/09/16 00:00 | Newell's v River Plate | W | 1-4 |
| Argentina Liga Profesional | 2021/09/06 00:15 | River Plate v CA Independiente | D | 1-1 |
| Argentina Liga Profesional | 2021/08/30 22:00 | Sarmiento v River Plate | W | 1-2 |
| Argentina Liga Profesional | 2021/08/27 00:00 | River Plate v CA Aldosivi | W | 2-0 |
Away History
| Argentina Liga Profesional | 2021/10/11 19:45 | San Lorenzo v Colon | L | 1-2 |
| Argentina Liga Profesional | 2021/10/02 21:00 | Atlético Tucumán v San Lorenzo | D | 0-0 |
| Argentina Liga Profesional | 2021/09/26 18:45 | San Lorenzo v Defensa y Justicia | W | 2-1 |
| Argentina Liga Profesional | 2021/09/20 21:00 | Rosario Central v San Lorenzo | L | 1-0 |
| Argentina Liga Profesional | 2021/09/13 21:45 | San Lorenzo v Racing Club | D | 1-1 |
| Argentina Liga Profesional | 2021/09/04 21:00 | Platense v San Lorenzo | D | 1-1 |
| Argentina Liga Profesional | 2021/08/30 19:45 | San Lorenzo v Patronato Parana | W | 3-0 |
| Argentina Liga Profesional | 2021/08/26 21:45 | Estudiantes LP v San Lorenzo | L | 2-0 |