[7] Barcelona 0-1 Real Betis [5] 2021-12-04 15:15
Stadium: Camp Nou Round: 16
Referee: Pablo Gonzalez Fuertes Home Manager: Xavi Away Manager: Manuel Pellegrini
Head to Head
| Spain La Liga | 2021/02/07 20:00 | Real Betis v Barcelona | W | 2-3 |
| Spain La Liga | 2020/11/07 15:15 | Barcelona v Real Betis | W | 5-2 |
| Spain La Liga | 2020/02/09 20:00 | Real Betis v Barcelona | W | 2-3 |
| Spain La Liga | 2019/08/25 19:00 | Barcelona v Real Betis | W | 5-2 |
| Spain La Liga | 2019/03/17 19:45 | Real Betis v Barcelona | W | 1-4 |
| Spain La Liga | 2018/11/11 15:15 | Barcelona v Real Betis | L | 3-4 |
| Spain La Liga | 2018/01/21 19:45 | Real Betis v Barcelona | W | 0-5 |
| Spain La Liga | 2017/08/20 18:15 | Barcelona v Real Betis | W | 2-0 |
Home History
| Spain La Liga | 2021/11/27 20:00 | Villarreal v Barcelona | W | 1-3 |
| UEFA Champions League | 2021/11/23 20:00 | Barcelona v Benfica | D | 0-0 |
| Spain La Liga | 2021/11/20 20:00 | Barcelona v Espanyol | W | 1-0 |
| Spain La Liga | 2021/11/06 15:15 | Celta Vigo v Barcelona | D | 3-3 |
| UEFA Champions League | 2021/11/02 20:00 | Dynamo Kiev v Barcelona | W | 0-1 |
| Spain La Liga | 2021/10/30 19:00 | Barcelona v CD Alaves | D | 1-1 |
| Spain La Liga | 2021/10/27 17:00 | Rayo Vallecano v Barcelona | L | 1-0 |
| Spain La Liga | 2021/10/24 14:15 | Barcelona v Real Madrid | L | 1-2 |
Away History
| Spain Copa del Rey | 2021/12/01 20:00 | CFI Alicante v Real Betis | W | 0-4 |
| Spain La Liga | 2021/11/28 13:00 | Real Betis v Levante | W | 3-1 |
| UEFA Europa League | 2021/11/25 17:45 | Real Betis v Ferencvarosi TC | W | 2-0 |
| Spain La Liga | 2021/11/21 17:30 | Elche v Real Betis | W | 0-3 |
| Spain La Liga | 2021/11/07 20:00 | Real Betis v Sevilla | L | 0-2 |
| UEFA Europa League | 2021/11/04 20:00 | Bayer Leverkusen v Real Betis | L | 4-0 |
| Spain La Liga | 2021/10/31 15:15 | Atletico Madrid v Real Betis | L | 3-0 |
| Spain La Liga | 2021/10/27 18:00 | Real Betis v Valencia | W | 4-1 |