[16] Santa Clara 1-0 Guimaraes [7] 2021-12-17 19:00
Stadium: Estadio de Sao Miguel Round: 15
Referee: Hugo Serafim Coelho Magalhaes Silva Home Manager: Nuno Campos Away Manager: Pepa
Head to Head
| Portugal Primeira Liga | 2021/04/17 14:30 | Guimaraes v Santa Clara | L | 1-0 |
| Portugal Primeira Liga | 2020/12/21 20:15 | Santa Clara v Guimaraes | L | 0-4 |
| Portugal Cup | 2020/12/13 14:00 | Guimaraes v Santa Clara | W | 0-1 |
| Portugal Primeira Liga | 2020/07/24 18:00 | Santa Clara v Guimaraes | D | 2-2 |
| Portugal Primeira Liga | 2020/01/18 15:30 | Guimaraes v Santa Clara | L | 1-0 |
| Portugal Primeira Liga | 2019/03/30 20:30 | Santa Clara v Guimaraes | W | 1-0 |
| Portugal Primeira Liga | 2018/11/11 15:00 | Guimaraes v Santa Clara | L | 2-0 |
| Europe Friendlies | 2018/07/22 10:00 | Guimaraes v Santa Clara | L | 3-2 |
Home History
| Portugal Primeira Liga | 2021/12/11 15:30 | Maritimo v Santa Clara | L | 4-1 |
| Portugal Primeira Liga | 2021/12/05 15:30 | Santa Clara v Arouca | W | 2-1 |
| Portugal Primeira Liga | 2021/11/29 20:15 | Estoril v Santa Clara | D | 2-2 |
| Portugal Cup | 2021/11/20 18:00 | Braga v Santa Clara | L | 6-0 |
| Portugal Primeira Liga | 2021/11/07 17:00 | Santa Clara v FC Porto | L | 0-3 |
| Portugal Primeira Liga | 2021/10/31 18:00 | Belenenses v Santa Clara | L | 2-1 |
| Portugal League Cup | 2021/10/26 18:00 | Santa Clara v FC Porto | W | 3-1 |
| Portugal Primeira Liga | 2021/10/23 14:30 | Santa Clara v Famalicao | L | 0-2 |
Away History
| Portugal Primeira Liga | 2021/12/11 18:00 | Guimaraes v Tondela | W | 5-2 |
| Portugal Primeira Liga | 2021/12/04 20:30 | Pacos Ferreira v Guimaraes | W | 1-2 |
| Portugal Primeira Liga | 2021/11/28 20:30 | FC Porto v Guimaraes | L | 2-1 |
| Portugal Cup | 2021/11/21 16:45 | Moreirense v Guimaraes | L | 3-2 |
| Portugal Primeira Liga | 2021/11/06 20:30 | Guimaraes v Moreirense | W | 2-1 |
| Portugal Primeira Liga | 2021/10/30 20:15 | Sporting v Guimaraes | L | 1-0 |
| Portugal League Cup | 2021/10/27 18:30 | Guimaraes v Benfica | D | 3-3 |
| Portugal Primeira Liga | 2021/10/22 19:15 | Guimaraes v Maritimo | W | 2-1 |