[3] FC Giessen 0-1 Mainz II [2] 2021-08-21 12:00
Stadium: Waldstadion Round: 2
Referee: Niclas Zemke Home Manager: Daniyel Cimen Away Manager: Bartosch Gaul
Head to Head
| Germany Regionalliga South West | 2021/03/20 13:00 | FC Giessen v Mainz II | D | 1-1 |
| Germany Regionalliga South West | 2021/01/12 18:00 | Mainz II v FC Giessen | L | 2-1 |
| Germany Regionalliga South West | 2019/09/15 12:00 | Mainz II v FC Giessen | W | 1-3 |
Home History
| Germany Regionalliga South West | 2021/08/14 12:00 | FC Astoria Walldorf v FC Giessen | W | 0-1 |
| Europe Friendlies | 2021/07/20 14:00 | Eintracht Frankfurt v FC Giessen | L | 6-1 |
| Europe Friendlies | 2021/07/17 12:00 | Waldhof Mannheim v FC Giessen | L | 5-3 |
| Elite Club Friendlies | 2021/07/13 16:30 | FC Giessen v Borussia Dortmund | L | 0-2 |
| Germany Regionalliga South West | 2021/06/12 12:00 | FC Giessen v Hessen Kassel | W | 3-1 |
| Germany Regionalliga South West | 2021/06/05 12:00 | TSV Eintracht Stadtallendorf v FC Giessen | W | 1-3 |
| Germany Regionalliga South West | 2021/05/29 12:00 | FC Giessen v TSV Schott Mainz | W | 5-0 |
| Germany Regionalliga South West | 2021/05/22 12:00 | VfB Stuttgart II v FC Giessen | D | 1-1 |
Away History
| Germany Regionalliga South West | 2021/08/14 12:00 | Mainz II v VfR Aalen | W | 3-1 |
| Europe Friendlies | 2021/08/04 13:00 | Fortuna Dusseldorf II v Mainz II | W | 0-1 |
| Germany Regionalliga South West | 2021/06/11 17:00 | Kickers Offenbach v Mainz II | L | 1-0 |
| Germany Regionalliga South West | 2021/06/05 12:00 | Mainz II v SG Sonnenhof Grossaspach | L | 0-1 |
| Germany Regionalliga South West | 2021/05/29 12:00 | Bahlinger SC v Mainz II | L | 2-1 |
| Germany Regionalliga South West | 2021/05/22 12:00 | Pirmasens v Mainz II | L | 2-0 |
| Germany Regionalliga South West | 2021/05/16 12:00 | Mainz II v VfR Aalen | W | 3-1 |
| Germany Regionalliga South West | 2021/05/08 12:00 | FC Astoria Walldorf v Mainz II | L | 4-2 |