[6] TSG Hoffenheim II 0-1 Mainz II [1] 2021-10-08 15:00
Stadium: Dietmar-Hopp-Stadion Round: 12
Referee: Arianit Besiri Home Manager: Kai Herdling Away Manager: Bartosch Gaul
Head to Head
| Germany Regionalliga South West | 2021/02/06 13:00 | Mainz II v TSG 1899 Hoffenheim II | W | 0-1 |
| Germany Regionalliga South West | 2020/09/05 12:00 | TSG 1899 Hoffenheim II v Mainz II | L | 1-2 |
| Germany Regionalliga South West | 2020/03/07 14:00 | TSG 1899 Hoffenheim II v Mainz II | L | 1-4 |
| Germany Regionalliga South West | 2019/08/25 12:00 | Mainz II v TSG 1899 Hoffenheim II | W | 0-2 |
| Germany Regionalliga South West | 2019/03/29 15:00 | Mainz II v TSG 1899 Hoffenheim II | D | 2-2 |
| Germany Regionalliga South West | 2018/09/23 12:00 | TSG 1899 Hoffenheim II v Mainz II | W | 3-0 |
| Germany Regionalliga South West | 2018/03/23 18:00 | TSG 1899 Hoffenheim II v Mainz II | W | 2-0 |
| Germany Regionalliga South West | 2017/09/28 16:00 | Mainz II v TSG 1899 Hoffenheim II | W | 0-1 |
Home History
| Germany Regionalliga South West | 2021/10/02 12:00 | FC Astoria Walldorf v TSG 1899 Hoffenheim II | W | 2-5 |
| Germany Regionalliga South West | 2021/09/28 17:00 | TSG 1899 Hoffenheim II v Hessen Kassel | W | 2-0 |
| Germany Regionalliga South West | 2021/09/18 12:00 | Rot-Weiss Koblenz v TSG 1899 Hoffenheim II | W | 0-2 |
| Germany Regionalliga South West | 2021/09/14 17:00 | TSG 1899 Hoffenheim II v SSV Ulm 1846 | L | 1-2 |
| Germany Regionalliga South West | 2021/09/10 17:00 | Kickers Offenbach v TSG 1899 Hoffenheim II | L | 1-0 |
| Germany Regionalliga South West | 2021/09/04 12:00 | TSG 1899 Hoffenheim II v Elversberg | L | 1-2 |
| Germany Regionalliga South West | 2021/08/28 12:00 | FC 08 Homburg v TSG 1899 Hoffenheim II | D | 3-3 |
| Germany Regionalliga South West | 2021/08/24 17:00 | TSG 1899 Hoffenheim II v FSV Frankfurt | W | 3-1 |
Away History
| Germany Regionalliga South West | 2021/10/02 12:00 | Mainz II v Rot-Weiss Koblenz | W | 2-1 |
| Germany Regionalliga South West | 2021/09/28 17:00 | SSV Ulm 1846 v Mainz II | W | 0-2 |
| Germany Regionalliga South West | 2021/09/25 12:00 | Mainz II v Kickers Offenbach | W | 2-0 |
| Germany Regionalliga South West | 2021/09/18 12:00 | Elversberg v Mainz II | L | 5-0 |
| Germany Regionalliga South West | 2021/09/14 16:00 | Mainz II v FC 08 Homburg | L | 1-2 |
| Germany Regionalliga South West | 2021/09/10 17:00 | FSV Frankfurt v Mainz II | W | 1-2 |
| Germany Regionalliga South West | 2021/09/03 12:00 | Mainz II v VfB Stuttgart II | L | 2-4 |
| Germany Regionalliga South West | 2021/08/29 12:00 | SG Sonnenhof Grossaspach v Mainz II | W | 1-3 |