[1] Mainz II 1-3 KSV Hessen Kassel [13] 2021-10-16 12:00
Stadium: Stadion am Bruchweg Round: 13
Referee: Marvin Maier Home Manager: Bartosch Gaul Away Manager: Tobias Damm
Head to Head
| Germany Regionalliga South West | 2021/04/17 12:00 | Mainz II v Hessen Kassel | W | 2-1 |
| Germany Regionalliga South West | 2020/10/24 12:00 | Hessen Kassel v Mainz II | L | 2-1 |
| Germany Regionalliga South West | 2018/04/07 12:00 | Mainz II v Hessen Kassel | D | 0-0 |
| Germany Regionalliga South West | 2017/10/15 12:00 | Hessen Kassel v Mainz II | W | 3-4 |
Home History
| Germany Regionalliga South West | 2021/10/08 15:00 | TSG 1899 Hoffenheim II v Mainz II | W | 0-1 |
| Germany Regionalliga South West | 2021/10/02 12:00 | Mainz II v Rot-Weiss Koblenz | W | 2-1 |
| Germany Regionalliga South West | 2021/09/28 17:00 | SSV Ulm 1846 v Mainz II | W | 0-2 |
| Germany Regionalliga South West | 2021/09/25 12:00 | Mainz II v Kickers Offenbach | W | 2-0 |
| Germany Regionalliga South West | 2021/09/18 12:00 | Elversberg v Mainz II | L | 5-0 |
| Germany Regionalliga South West | 2021/09/14 16:00 | Mainz II v FC 08 Homburg | L | 1-2 |
| Germany Regionalliga South West | 2021/09/10 17:00 | FSV Frankfurt v Mainz II | W | 1-2 |
| Germany Regionalliga South West | 2021/09/03 12:00 | Mainz II v VfB Stuttgart II | L | 2-4 |
Away History
| Germany Regionalliga South West | 2021/10/09 12:00 | Hessen Kassel v FC Astoria Walldorf | L | 0-2 |
| Germany Regionalliga South West | 2021/09/28 17:00 | TSG 1899 Hoffenheim II v Hessen Kassel | L | 2-0 |
| Germany Regionalliga South West | 2021/09/25 12:00 | Hessen Kassel v Rot-Weiss Koblenz | W | 2-0 |
| Germany Regionalliga South West | 2021/09/19 12:00 | SSV Ulm 1846 v Hessen Kassel | L | 2-1 |
| Germany Regionalliga South West | 2021/09/14 16:30 | Hessen Kassel v Kickers Offenbach | D | 0-0 |
| Germany Regionalliga South West | 2021/09/11 12:00 | Elversberg v Hessen Kassel | D | 0-0 |
| Germany Regionalliga South West | 2021/09/04 12:00 | Hessen Kassel v FC 08 Homburg | W | 3-0 |
| Germany Regionalliga South West | 2021/08/28 12:00 | FSV Frankfurt v Hessen Kassel | L | 1-0 |