[17] Southampton 1-0 Leeds [16] 2021-10-16 14:00
Stadium: St. Mary's Stadium Round: 8
Referee: David Coote Home Manager: Ralph Hasenhuttl Away Manager: Marcelo Bielsa
Head to Head
| England Premier League | 2021/05/18 17:00 | Southampton v Leeds | L | 0-2 |
| England Premier League | 2021/02/23 18:00 | Leeds v Southampton | L | 3-0 |
Home History
| England Premier League | 2021/10/02 14:00 | Chelsea v Southampton | L | 3-1 |
| England Premier League | 2021/09/26 13:00 | Southampton v Wolverhampton | L | 0-1 |
| England EFL Cup | 2021/09/21 18:45 | Sheff Utd v Southampton | W | 4-6 |
| England Premier League | 2021/09/18 14:00 | Man City v Southampton | D | 0-0 |
| England Premier League | 2021/09/11 14:00 | Southampton v West Ham | D | 0-0 |
| England Premier League | 2021/08/28 14:00 | Newcastle v Southampton | D | 2-2 |
| England EFL Cup | 2021/08/25 18:45 | Newport County v Southampton | W | 0-8 |
| England Premier League | 2021/08/22 13:00 | Southampton v Man Utd | D | 1-1 |
Away History
| England Premier League | 2021/10/02 14:00 | Leeds v Watford | W | 1-0 |
| England Premier League | 2021/09/25 14:00 | Leeds v West Ham | L | 1-2 |
| England EFL Cup | 2021/09/21 18:45 | Fulham v Leeds | W | 5-6 |
| England Premier League | 2021/09/17 19:00 | Newcastle v Leeds | D | 1-1 |
| England Premier League | 2021/09/12 15:30 | Leeds v Liverpool | L | 0-3 |
| England Premier League | 2021/08/29 13:00 | Burnley v Leeds | D | 1-1 |
| England EFL Cup | 2021/08/24 18:45 | Leeds v Crewe | W | 3-0 |
| England Premier League | 2021/08/21 14:00 | Leeds v Everton | D | 2-2 |