[3] America de Cali 3-1 Junior [9] 2021-07-17 20:30
Stadium: Olimpico Pascual Guerrero Round: 1
Referee: Eder Enrique Vergara Lora Home Manager: Juan Carlos Osorio Away Manager: Luis Amaranto Perea Mosquera
Head to Head
| Colombia Primera A | 2021/01/31 01:10 | Junior v America de Cali | L | 2-1 |
| Colombia Primera A | 2020/12/14 01:00 | Junior v America de Cali | W | 1-2 |
| Colombia Primera A | 2020/12/07 01:00 | America de Cali v Junior | D | 0-0 |
| Colombia Primera A | 2020/10/15 01:10 | Junior v America de Cali | D | 1-1 |
| Colombia Super Cup | 2020/09/12 00:00 | America de Cali v Junior | L | 0-2 |
| Colombia Super Cup | 2020/09/09 00:30 | Junior v America de Cali | W | 1-2 |
| Colombia Primera A | 2019/12/07 21:00 | America de Cali v Junior | W | 2-0 |
| Colombia Primera A | 2019/12/02 00:00 | Junior v America de Cali | D | 0-0 |
Home History
| Copa Sudamericana | 2021/07/14 00:30 | America de Cali v Athletico Paranaense | L | 0-1 |
| Copa Libertadores | 2021/05/26 00:30 | Cerro Porteno v America de Cali | L | 1-0 |
| Copa Libertadores | 2021/05/20 02:00 | America de Cali v Deportivo La Guaira | W | 3-1 |
| Copa Libertadores | 2021/05/14 00:00 | America de Cali v Atletico Mineiro | L | 1-3 |
| Copa Libertadores | 2021/05/07 02:00 | Deportivo La Guaira v America de Cali | D | 0-0 |
| Colombia Primera A | 2021/05/01 23:00 | Millonarios v America de Cali | D | 0-0 |
| Copa Libertadores | 2021/04/27 22:15 | Atletico Mineiro v America de Cali | L | 2-1 |
| Colombia Primera A | 2021/04/24 20:30 | America de Cali v Millonarios | L | 1-2 |
Away History
| Copa Sudamericana | 2021/07/15 00:30 | Junior v Libertad Asuncion | L | 3-4 |
| Colombia Primera A | 2021/06/13 18:30 | Millonarios v Junior | L | 2-0 |
| Colombia Primera A | 2021/06/10 21:00 | Junior v Millonarios | W | 3-2 |
| Copa Libertadores | 2021/05/25 22:15 | Independiente Santa Fe v Junior | D | 0-0 |
| Copa Libertadores | 2021/05/19 00:30 | Fluminense v Junior | W | 1-2 |
| Copa Libertadores | 2021/05/13 00:00 | Junior v River Plate | D | 1-1 |
| Copa Libertadores | 2021/05/07 00:00 | Junior v Fluminense | D | 1-1 |
| Colombia Primera A | 2021/05/02 18:00 | Independiente Santa Fe v Junior | D | 0-0 |