[7] Cologne II 2-1 Schalke II [14] 2021-12-13 13:00
Stadium: Franz-Kremer-Stadion Round: 20
Referee: Francisco-Javier Lahora Chulian Home Manager: Mark Zimmermann Away Manager: Torsten Frohling
Head to Head
| Germany Regionalliga West | 2021/08/15 13:00 | Schalke II v Cologne II | W | 1-2 |
| Germany Regionalliga West | 2021/03/20 14:30 | Cologne II v Schalke II | W | 5-2 |
| Germany Regionalliga West | 2020/10/21 17:30 | Schalke II v Cologne II | L | 3-0 |
| Germany Regionalliga West | 2019/11/09 13:00 | Cologne II v Schalke II | W | 3-0 |
| Germany Regionalliga West | 2016/12/03 13:00 | Cologne II v Schalke II | W | 2-1 |
| Germany Regionalliga West | 2016/08/05 12:00 | Schalke II v Cologne II | W | 0-1 |
| Germany Regionalliga West | 2016/03/11 18:30 | Cologne II v Schalke II | L | 0-1 |
| Germany Regionalliga West | 2015/09/19 12:00 | Schalke II v Cologne II | D | 1-1 |
Home History
| Germany Regionalliga West | 2021/12/08 18:30 | SC Fortuna Köln v Cologne II | D | 1-1 |
| Germany Regionalliga West | 2021/12/04 13:00 | Cologne II v SC Preussen Munster | D | 1-1 |
| Germany Regionalliga West | 2021/11/27 13:00 | VfB Homberg v Cologne II | W | 1-3 |
| Germany Regionalliga West | 2021/11/21 17:00 | Cologne II v Fortuna Dusseldorf II | D | 1-1 |
| Germany Regionalliga West | 2021/11/05 18:00 | Cologne II v Wuppertaler | L | 0-3 |
| Germany Regionalliga West | 2021/10/30 12:00 | SV Straelen v Cologne II | W | 1-2 |
| Germany Regionalliga West | 2021/10/27 12:00 | Cologne II v SV Rodinghausen | L | 2-3 |
| Germany Regionalliga West | 2021/10/23 12:00 | Cologne II v Rot-Weiss Essen | D | 1-1 |
Away History
| Germany Regionalliga West | 2021/12/04 13:00 | SC Wiedenbruck v Schalke II | D | 2-2 |
| Germany Regionalliga West | 2021/11/26 18:30 | Schalke II v KFC Uerdingen 05 | W | 4-1 |
| Germany Regionalliga West | 2021/11/20 13:00 | Rot-Weiss Oberhausen v Schalke II | L | 4-0 |
| Germany Regionalliga West | 2021/11/13 13:00 | Schalke II v SV Lippstadt 08 | W | 2-1 |
| Germany Regionalliga West | 2021/11/07 13:00 | Bonner SC v Schalke II | L | 4-3 |
| Germany Regionalliga West | 2021/10/29 17:00 | SC Preussen Munster v Schalke II | L | 3-0 |
| Germany Regionalliga West | 2021/10/23 12:00 | Schalke II v VfB Homberg | D | 0-0 |
| Germany Regionalliga West | 2021/10/15 16:30 | Fortuna Dusseldorf II v Schalke II | L | 5-1 |