[7] Leones 2-1 CD Real Santander [9] 2021-08-20 01:00
Stadium: Estadio Metropolitano Ciudad de Itagui Round: 5
Head to Head
| Colombia Cup | 2021/04/21 20:15 | Real San Andres v Leones | L | 2-0 |
| Colombia Cup | 2021/04/15 00:40 | Leones v Real San Andres | L | 1-3 |
| Colombia Primera B | 2021/04/09 20:30 | Leones v Real San Andres | W | 2-0 |
| Colombia Primera B | 2020/11/02 20:30 | Real San Andres v Leones | W | 0-3 |
| Colombia Primera B | 2019/10/06 20:30 | Real San Andres v Leones | L | 3-1 |
| Colombia Primera B | 2019/04/28 20:00 | Leones v Real San Andres | W | 3-0 |
| Colombia Primera B | 2017/10/01 20:30 | Leones v Real San Andres | W | 1-0 |
| Colombia Primera B | 2017/08/20 23:00 | Real San Andres v Leones | D | 1-1 |
Home History
| Colombia Primera B | 2021/08/14 20:00 | Fortaleza CEIF v Leones | L | 3-1 |
| Colombia Primera B | 2021/08/09 22:30 | Leones v Boyaca Chico | D | 0-0 |
| Colombia Primera B | 2021/07/31 20:00 | Valledupar FC v Leones | D | 1-1 |
| Colombia Primera B | 2021/07/24 22:30 | Leones v Orsomarso | W | 1-0 |
| Colombia Primera B | 2021/06/16 21:00 | Internacional FC de Palmira v Leones | L | 3-0 |
| Colombia Primera B | 2021/05/05 20:15 | Leones v Fortaleza CEIF | W | 3-0 |
| Colombia Primera B | 2021/05/03 00:30 | Atletico Huila v Leones | W | 0-2 |
| Colombia Primera B | 2021/04/29 00:40 | Leones v Atletico Huila | D | 1-1 |
Away History
| Colombia Primera B | 2021/08/14 20:00 | Real San Andres v Real Cartagena | D | 2-2 |
| Colombia Primera B | 2021/08/08 20:00 | Boca Juniors De Cali v Real San Andres | D | 0-0 |
| Colombia Cup | 2021/08/04 20:00 | Real San Andres v Patriotas FC | D | 7-7 |
| Colombia Primera B | 2021/07/31 19:00 | Real San Andres v Union Magdalena | D | 3-3 |
| Colombia Cup | 2021/07/28 20:00 | Patriotas FC v Real San Andres | L | 1-0 |
| Colombia Cup | 2021/04/21 20:15 | Real San Andres v Leones | W | 2-0 |
| Colombia Cup | 2021/04/15 00:40 | Leones v Real San Andres | W | 1-3 |
| Colombia Primera B | 2021/04/09 20:30 | Leones v Real San Andres | L | 2-0 |