[10] Istanbulspor 2-1 Eyupspor [4] 2021-12-11 16:00
Stadium: Esenyurt Necmi Kadioglu Stadium Round: 16
Referee: Sarper Baris Saka Home Manager: Osman Zeki Korkmaz Away Manager: Zafer Turan
Home History
| Türkiye 1 Lig | 2021/12/04 10:30 | Erzurum BB v Istanbulspor | L | 3-1 |
| Türkiye Cup | 2021/11/30 11:00 | Istanbulspor v Afjet Afyonspor | L | 2-3 |
| Türkiye 1 Lig | 2021/11/27 10:30 | Istanbulspor v Denizlispor | D | 1-1 |
| Türkiye 1 Lig | 2021/11/20 16:00 | Bursaspor v Istanbulspor | W | 2-4 |
| Türkiye 1 Lig | 2021/11/05 17:00 | Istanbulspor v Menemen Belediye Spor | W | 3-2 |
| Türkiye 1 Lig | 2021/10/31 16:00 | Genclerbirligi v Istanbulspor | W | 0-2 |
| Türkiye Cup | 2021/10/27 11:00 | Istanbulspor v Ergene Velimese Spor | W | 5-0 |
| Türkiye 1 Lig | 2021/10/23 10:30 | Keciorengucu v Istanbulspor | L | 3-2 |
Away History
| Türkiye Cup | 2021/12/01 18:00 | Hatayspor v Eyupspor | D | 1-1 |
| Türkiye 1 Lig | 2021/11/27 13:00 | Boluspor v Eyupspor | L | 3-1 |
| Türkiye 1 Lig | 2021/11/22 16:00 | Eyupspor v Samsunspor | D | 2-2 |
| Türkiye 1 Lig | 2021/11/06 16:00 | Altinordu v Eyupspor | W | 1-2 |
| Türkiye 1 Lig | 2021/10/30 16:00 | Eyupspor v Ankaragucu | W | 2-0 |
| Türkiye Cup | 2021/10/26 11:00 | Eyupspor v Bucaspor | W | 2-0 |
| Türkiye 1 Lig | 2021/10/22 17:00 | Eyupspor v Adanaspor | W | 1-0 |
| Türkiye 1 Lig | 2021/10/16 10:30 | Umraniyespor v Eyupspor | D | 2-2 |