[3] Deportes Tolima 0-1 America de Cali [14] 2021-10-29 01:10
Stadium: Estadio Manuel Murillo Toro Round: 16
Referee: Lisandro Enrique Castillo Forero Home Manager: Hernan Torres Away Manager: Juan Carlos Osorio
Head to Head
| Colombia Primera A | 2021/04/18 20:30 | America de Cali v Deportes Tolima | L | 2-0 |
| Colombia Primera A | 2020/09/27 01:10 | Deportes Tolima v America de Cali | W | 1-0 |
| Colombia Primera A | 2019/07/21 00:45 | Deportes Tolima v America de Cali | L | 0-1 |
| Colombia Primera A | 2019/02/01 01:00 | America de Cali v Deportes Tolima | L | 3-1 |
| Colombia Primera A | 2018/07/29 00:45 | Deportes Tolima v America de Cali | W | 1-0 |
| Colombia Primera A | 2018/02/10 23:00 | America de Cali v Deportes Tolima | D | 1-1 |
| Colombia Primera A | 2017/07/16 00:45 | America de Cali v Deportes Tolima | L | 3-0 |
| Colombia Primera A | 2017/02/08 01:00 | Deportes Tolima v America de Cali | W | 2-1 |
Home History
| Colombia Primera A | 2021/10/23 23:05 | Independiente Medellin v Deportes Tolima | D | 2-2 |
| Colombia Cup | 2021/10/20 22:30 | Deportivo Pereira v Deportes Tolima | L | 6-5 |
| Colombia Primera A | 2021/10/16 00:40 | Deportes Tolima v Atletico Huila | W | 1-0 |
| Colombia Primera A | 2021/10/09 19:00 | Once Caldas v Deportes Tolima | W | 0-2 |
| Colombia Cup | 2021/10/06 23:00 | Deportes Tolima v Deportivo Pereira | D | 0-0 |
| Colombia Primera A | 2021/10/01 23:00 | Deportes Tolima v Independiente Santa Fe | D | 0-0 |
| Colombia Primera A | 2021/09/26 19:00 | Patriotas FC v Deportes Tolima | D | 0-0 |
| Colombia Primera A | 2021/09/19 21:00 | Deportes Tolima v Deportivo Cali | D | 1-1 |
Away History
| Colombia Primera A | 2021/10/24 23:05 | America de Cali v Atletico Nacional Medellin | L | 0-2 |
| Colombia Super Cup | 2021/10/21 01:00 | Independiente Santa Fe v America de Cali | L | 3-2 |
| Colombia Primera A | 2021/10/16 21:00 | America de Cali v Deportivo Cali | D | 1-1 |
| Colombia Primera A | 2021/10/09 23:05 | Millonarios v America de Cali | D | 0-0 |
| Colombia Super Cup | 2021/10/06 00:45 | America de Cali v Independiente Santa Fe | L | 1-2 |
| Colombia Primera A | 2021/10/03 01:10 | America de Cali v Atletico Huila | W | 1-0 |
| Colombia Primera A | 2021/09/26 01:10 | Atletico Bucaramanga v America de Cali | L | 2-1 |
| Colombia Primera A | 2021/09/18 21:00 | America de Cali v Jaguares de Cordoba | L | 2-3 |