[157] Evgeny Donskoy 5-7,6-3,6-7 John Isner [39] 2021-07-22 02:15
Stadium: Grandstand Caliente Round: 26 Ground: Hardcourt outdoor
Home History
| ATP Los Cabos | 2021/07/20 00:00 | Jason Jung v Evgeny Donskoy | 1-6,4-6 |
| ATP Newport | 2021/07/12 16:00 | Jenson Brooksby v Evgeny Donskoy | 7-5,6-3 |
| Wimbledon | 2021/06/22 15:45 | Frederico Ferreira Silva v Evgeny Donskoy | 7-5,6-3 |
| Challenger Nottingham | 2021/06/15 10:00 | Damir Dzumhur v Evgeny Donskoy | 7-6,6-2 |
| Challenger Nottingham | 2021/06/11 12:00 | Evgeny Donskoy v Frances Tiafoe | 6-7,6-2,3-6 |
| Challenger Nottingham | 2021/06/09 11:30 | Evgeny Donskoy v Brandon Nakashima | 7-6,7-6 |
| Challenger Nottingham | 2021/06/07 16:00 | Mackenzie McDonald v Evgeny Donskoy | 3-6,5-7 |
| French Open | 2021/05/26 16:25 | Marco Trungelliti v Evgeny Donskoy | 6-7,6-2,6-3 |
Away History
| Wimbledon | 2021/06/30 10:00 | Yoshihito Nishioka v John Isner | 7-6,2-6,6-3,6-7,6-4 |
| French Open | 2021/06/04 19:00 | Stefanos Tsitsipas v John Isner | 5-7,6-3,7-6,6-1 |
| French Open | 2021/06/02 12:35 | Filip Krajinovic v John Isner | 6-7,1-6,6-7 |
| French Open | 2021/05/31 09:00 | Sam Querrey v John Isner | 6-7,3-6,4-6 |
| ATP Madrid | 2021/05/07 11:00 | Dominic Thiem v John Isner | 3-6,6-3,6-4 |
| ATP Madrid | 2021/05/06 13:20 | John Isner v Andrey Rublev | 7-6,3-6,7-6 |
| ATP Madrid | 2021/05/05 16:00 | Roberto Bautista-Agut v John Isner | 4-6,7-6,6-7 |
| ATP Madrid | 2021/05/03 09:00 | John Isner v Miomir Kecmanovic | 6-4,7-6 |