[10] Guadalupe FC 0-5 Santos de Guápiles [4] 2021-11-28 21:00
Stadium: Estadio Coyella Fonseca Round: 22
Head to Head
| Costa Rica Primera Division | 2021/09/16 23:00 | Santos de Guápiles v Guadalupe FC | D | 2-2 |
| Costa Rica Primera Division | 2021/04/03 23:00 | Guadalupe FC v Santos de Guápiles | L | 2-4 |
| Costa Rica Primera Division | 2021/02/01 00:00 | Santos de Guápiles v Guadalupe FC | D | 2-2 |
| Costa Rica Primera Division | 2020/11/05 23:00 | Santos de Guápiles v Guadalupe FC | D | 1-1 |
| Costa Rica Primera Division | 2020/08/15 21:00 | Guadalupe FC v Santos de Guápiles | D | 2-2 |
| Costa Rica Primera Division | 2020/03/08 23:00 | Santos de Guápiles v Guadalupe FC | W | 3-4 |
| Costa Rica Primera Division | 2020/02/20 02:00 | Guadalupe FC v Santos de Guápiles | W | 1-0 |
| Costa Rica Primera Division | 2019/09/19 00:00 | Guadalupe FC v Santos de Guápiles | L | 2-4 |
Home History
| Costa Rica Primera Division | 2021/11/25 02:00 | Alajuelense v Guadalupe FC | L | 1-0 |
| Costa Rica Primera Division | 2021/11/21 17:00 | AD Grecia v Guadalupe FC | D | 0-0 |
| Costa Rica Primera Division | 2021/10/30 19:30 | Guadalupe FC v ADR Jicaral | W | 2-0 |
| Costa Rica Primera Division | 2021/10/27 01:00 | Guadalupe FC v Cartagines | D | 1-1 |
| Costa Rica Primera Division | 2021/10/23 21:00 | Sporting San Jose v Guadalupe FC | L | 2-0 |
| Costa Rica Primera Division | 2021/10/17 21:00 | Guadalupe FC v Municipal Perez Zeledon | L | 0-1 |
| Costa Rica Primera Division | 2021/10/15 02:00 | Deportivo Saprissa v Guadalupe FC | L | 4-0 |
| Costa Rica Primera Division | 2021/10/01 22:00 | Guadalupe FC v AD Guanacasteca | D | 1-1 |
Away History
| Costa Rica Primera Division | 2021/11/24 23:00 | Santos de Guápiles v Cartagines | L | 1-2 |
| Costa Rica Primera Division | 2021/11/20 23:00 | AD San Carlos v Santos de Guápiles | W | 2-4 |
| CONCACAF League | 2021/11/03 00:00 | Forge FC v Santos de Guápiles | L | 3-0 |
| Costa Rica Primera Division | 2021/10/30 22:30 | Santos de Guápiles v Municipal Perez Zeledon | W | 3-2 |
| Costa Rica Primera Division | 2021/10/27 23:00 | Herediano v Santos de Guápiles | D | 1-1 |
| Costa Rica Primera Division | 2021/10/24 20:00 | Santos de Guápiles v ADR Jicaral | L | 2-3 |
| CONCACAF League | 2021/10/20 22:00 | Santos de Guápiles v Forge FC | W | 3-1 |
| Costa Rica Primera Division | 2021/10/17 20:00 | AD Guanacasteca v Santos de Guápiles | W | 1-3 |