[18] Alessandria 1-3 Ascoli [6] 2021-09-21 16:00
Stadium: Stadio Giuseppe Moccagatta Round: 5
Referee: Daniele Minelli Home Manager: Moreno Longo Away Manager: Andrea Sottil
Home History
| Italy Serie B | 2021/09/18 12:00 | Lecce v Alessandria | L | 3-2 |
| Italy Serie B | 2021/09/11 12:00 | Alessandria v Brescia | L | 1-3 |
| Europe Friendlies | 2021/09/04 13:00 | Alessandria v Genoa | W | 3-2 |
| Italy Serie B | 2021/08/27 16:00 | Pisa v Alessandria | L | 2-0 |
| Italy Serie B | 2021/08/22 18:30 | Benevento v Alessandria | L | 4-3 |
| Coppa Italia | 2021/08/16 19:00 | Sampdoria v Alessandria | L | 3-2 |
| Europe Friendlies | 2021/08/11 15:00 | Atalanta v Alessandria | L | 7-1 |
| Coppa Italia | 2021/08/08 18:30 | Padova v Alessandria | W | 0-2 |
Away History
| Italy Serie B | 2021/09/18 12:00 | Ascoli v Benevento | L | 0-2 |
| Italy Serie B | 2021/09/11 12:00 | Como v Ascoli | W | 0-1 |
| Italy Serie B | 2021/08/28 18:30 | Perugia v Ascoli | W | 2-3 |
| Italy Serie B | 2021/08/22 18:30 | Ascoli v Cosenza | W | 1-0 |
| Coppa Italia | 2021/08/13 18:45 | Udinese v Ascoli | L | 3-1 |
| Elite Club Friendlies | 2021/08/08 15:30 | Napoli v Ascoli | L | 2-1 |
| Europe Friendlies | 2021/07/31 15:00 | Ascoli v Viterbese | W | 2-0 |
| Italy Serie B | 2021/05/10 12:00 | AC Chievo Verona v Ascoli | L | 3-0 |