Home History
| England Premier League 2 | 2021/09/10 18:00 | Fulham U23 v Southampton U23 | L | 3-0 |
| England U23 Premier League Cup | 2021/09/02 18:00 | Arsenal U23 v Southampton U23 | D | 1-1 |
| England Premier League 2 | 2021/08/29 11:00 | Middlesbrough U23 v Southampton U23 | L | 2-1 |
| England Premier League 2 | 2021/08/23 18:00 | Nottm Forest U23 v Southampton U23 | D | 0-0 |
| England Premier League 2 | 2021/08/15 13:00 | Southampton U23 v Norwich U23 | L | 0-3 |
| England Premier League 2 | 2021/05/07 18:00 | Everton U23 v Southampton U23 | L | 4-0 |
| England Premier League 2 | 2021/05/02 13:00 | Southampton U23 v Everton U23 | L | 0-5 |
| England Premier League 2 | 2021/04/19 18:00 | Leicester U23 v Southampton U23 | L | 7-1 |
Away History
| England Premier League 2 | 2021/09/10 18:00 | Burnley U23 v Wolverhampton U23 | D | 1-1 |
| England Premier League 2 | 2021/08/27 18:00 | Newcastle U23 v Burnley U23 | L | 2-0 |
| England Premier League 2 | 2021/08/23 18:00 | Burnley U23 v Sunderland U23 | L | 2-3 |
| England Premier League 2 | 2021/08/16 18:00 | West Brom U23 v Burnley U23 | L | 3-2 |
| England Premier League 2 | 2021/05/03 12:00 | Leeds U23 v Burnley U23 | L | 5-2 |
| England Premier League 2 | 2021/04/16 12:00 | Reading U23 v Burnley U23 | W | 0-2 |
| England Premier League 2 | 2021/04/12 13:00 | Burnley U23 v Norwich U23 | D | 2-2 |
| England Premier League 2 | 2021/03/29 12:00 | Sunderland U23 v Burnley U23 | L | 3-0 |