Head to Head
| England Premier League 2 | 2021/10/18 11:00 | Wolverhampton U23 v Southampton U23 | W | 0-1 |
| England Premier League 2 | 2020/02/03 19:00 | Southampton U23 v Wolverhampton U23 | W | 1-0 |
| England Premier League 2 | 2019/09/27 18:00 | Wolverhampton U23 v Southampton U23 | W | 1-2 |
| England Premier League 2 | 2019/03/11 19:00 | Wolverhampton U23 v Southampton U23 | L | 3-1 |
| England Premier League 2 | 2018/10/19 18:00 | Southampton U23 v Wolverhampton U23 | W | 3-2 |
| England Premier League 2 | 2017/12/11 19:00 | Southampton U23 v Wolverhampton U23 | L | 2-4 |
| England Premier League 2 | 2017/08/21 18:00 | Wolverhampton U23 v Southampton U23 | L | 3-0 |
Home History
| England Premier League 2 | 2021/12/17 19:00 | Norwich U23 v Southampton U23 | L | 4-3 |
| England U23 Premier League Cup | 2021/12/12 14:00 | Southampton U23 v Arsenal U23 | L | 2-3 |
| England Premier League 2 | 2021/12/06 16:00 | Stoke U23 v Southampton U23 | L | 3-0 |
| England Premier League 2 | 2021/11/28 14:00 | Southampton U23 v West Brom U23 | W | 3-1 |
| England U23 Premier League Cup | 2021/11/24 19:00 | Southampton U23 v Bournemouth U23 | W | 1-0 |
| England Premier League 2 | 2021/11/21 12:00 | Sunderland U23 v Southampton U23 | L | 3-2 |
| England Premier League 2 | 2021/11/05 12:00 | Southampton U23 v Newcastle U23 | W | 5-0 |
| England Premier League 2 | 2021/10/31 14:00 | Southampton U23 v Aston Villa U23 | W | 4-0 |
Away History
| England U23 Premier League Cup | 2021/12/13 14:00 | West Ham U23 v Wolverhampton U23 | D | 0-0 |
| England Premier League 2 | 2021/12/03 19:00 | Fulham U23 v Wolverhampton U23 | L | 4-2 |
| England Premier League 2 | 2021/11/29 19:00 | Wolverhampton U23 v Norwich U23 | L | 0-5 |
| England U23 Premier League Cup | 2021/11/25 14:00 | Swansea U23 v Wolverhampton U23 | W | 0-2 |
| England Premier League 2 | 2021/11/19 19:00 | Birmingham U23 v Wolverhampton U23 | W | 1-2 |
| England Premier League 2 | 2021/11/05 19:00 | Wolverhampton U23 v West Brom U23 | D | 1-1 |
| England Premier League 2 | 2021/11/01 19:00 | Stoke U23 v Wolverhampton U23 | L | 2-0 |
| England Premier League 2 | 2021/10/25 18:00 | Newcastle U23 v Wolverhampton U23 | W | 2-3 |