Head to Head
| England Premier League 2 | 2021/10/25 18:00 | Reading U23 v Southampton U23 | W | 0-1 |
| England Premier League 2 | 2019/03/01 19:00 | Southampton U23 v Reading U23 | L | 1-2 |
| England Premier League 2 | 2018/09/29 12:00 | Reading U23 v Southampton U23 | L | 2-0 |
| England Premier League 2 | 2017/12/18 12:30 | Reading U23 v Southampton U23 | D | 1-1 |
| England Premier League 2 | 2017/01/06 13:00 | Reading U23 v Southampton U23 | L | 4-2 |
| England EFL Trophy | 2016/12/21 19:00 | Southampton U23 v Reading U23 | L | 4-5 |
| England Premier League 2 | 2016/09/12 18:00 | Southampton U23 v Reading U23 | W | 3-1 |
Home History
| England Premier League 2 | 2022/03/11 14:00 | Aston Villa U23 v Southampton U23 | D | 2-2 |
| England Premier League 2 | 2022/02/26 15:00 | Southampton U23 v Nottm Forest U23 | W | 4-2 |
| England Premier League 2 | 2022/02/21 19:00 | Southampton U23 v Birmingham U23 | L | 2-3 |
| England Premier League 2 | 2022/02/07 19:00 | West Brom U23 v Southampton U23 | W | 0-1 |
| England U23 Premier League Cup | 2022/01/27 12:00 | Southampton U23 v Bournemouth U23 | L | 0-1 |
| England Premier League 2 | 2022/01/23 14:00 | Southampton U23 v Middlesbrough U23 | W | 1-0 |
| England Premier League 2 | 2022/01/17 19:00 | Southampton U23 v Fulham U23 | W | 2-1 |
| England U23 Premier League Cup | 2022/01/13 19:00 | West Brom U23 v Southampton U23 | D | 2-2 |
Away History
| England Premier League 2 | 2022/03/14 19:00 | Reading U23 v Burnley U23 | W | 2-1 |
| England Premier League 2 | 2022/03/06 13:00 | Birmingham U23 v Reading U23 | D | 0-0 |
| England Premier League 2 | 2022/02/28 19:00 | Wolverhampton U23 v Reading U23 | L | 4-3 |
| England Premier League 2 | 2022/02/21 19:00 | Nottm Forest U23 v Reading U23 | L | 7-0 |
| England U23 Premier League Cup | 2022/02/14 13:00 | Reading U23 v Derby U23 | L | 1-3 |
| England Premier League 2 | 2022/02/07 19:00 | Reading U23 v Stoke U23 | D | 1-1 |
| England Premier League 2 | 2022/01/24 19:00 | Aston Villa U23 v Reading U23 | L | 4-1 |
| England U23 Premier League Cup | 2022/01/17 15:00 | Norwich U23 v Reading U23 | L | 3-1 |