[36] Reilly Opelka 3-6,6-7 John Millman [43] 2021-08-05 19:20
Stadium: Grandstand Round: 26 Ground: Hardcourt outdoor
Head to Head
| ATP Queens | 2021/06/14 11:30 | Reilly Opelka v John Millman | 6-7,7-5,6-7 |
| ATP Tokyo | 2019/10/05 04:00 | Reilly Opelka v John Millman | 3-6,6-7 |
Home History
| ATP Washington | 2021/08/04 19:45 | Reilly Opelka v Daniel Elahi Galan | 7-6,6-3 |
| ATP Atlanta | 2021/07/30 18:10 | Taylor Fritz v Reilly Opelka | 7-6,6-7,7-6 |
| ATP Atlanta | 2021/07/29 01:30 | Bjorn Fratangelo v Reilly Opelka | 6-7,6-7 |
| Wimbledon | 2021/06/28 16:15 | Reilly Opelka v Dominik Koepfer | 4-6,6-7,2-6 |
| ATP Queens | 2021/06/14 11:30 | Reilly Opelka v John Millman | 6-7,7-5,6-7 |
| French Open | 2021/06/04 13:40 | Reilly Opelka v Daniil Medvedev | 4-6,2-6,4-6 |
| French Open | 2021/06/02 13:45 | Reilly Opelka v Jaume Munar | 6-3,6-2,3-6,7-5 |
| French Open | 2021/05/31 12:15 | Reilly Opelka v Andrej Martin | 6-3,6-2,6-4 |
Away History
| ATP Washington | 2021/08/04 18:00 | Elias Ymer v John Millman | 2-6,6-7 |
| Olympics 2020 - Men | 2021/07/26 03:30 | John Millman v Alejandro Davidovich Fokina | 4-6,7-6,3-6 |
| Olympics 2020 - Men | 2021/07/24 02:00 | Lorenzo Musetti v John Millman | 3-6,4-6 |
| ATP Bastad | 2021/07/14 13:20 | Arthur Rinderknech v John Millman | 6-3,3-6,6-3 |
| Wimbledon | 2021/06/28 14:30 | John Millman v Roberto Bautista-Agut | 2-6,6-3,3-6,6-7 |
| ATP Eastbourne | 2021/06/23 12:00 | Lorenzo Sonego v John Millman | 6-4,6-2 |
| ATP Eastbourne | 2021/06/22 14:10 | John Millman v Jay Clarke | 6-3,6-2 |
| ATP Queens | 2021/06/16 11:00 | Alex De Minaur v John Millman | 6-1,6-3 |