[7] Andrey Rublev 5-7,6-7 John Isner [30] 2021-08-12 16:35
Stadium: Stadium Round: 26 Ground: Hardcourt outdoor
Head to Head
| ATP Madrid | 2021/05/06 13:20 | John Isner v Andrey Rublev | 7-6,3-6,7-6 |
| ATP Miami | 2015/03/28 18:45 | Andrey Rublev v John Isner | 3-6,4-6 |
Home History
| ATP Toronto | 2021/08/11 16:55 | Andrey Rublev v Fabio Fognini | 7-6,6-3 |
| Olympics 2020 - Men | 2021/07/25 08:15 | Kei Nishikori v Andrey Rublev | 6-3,6-4 |
| Wimbledon | 2021/07/05 11:55 | Marton Fucsovics v Andrey Rublev | 6-3,4-6,4-6,6-0,6-3 |
| Wimbledon | 2021/07/02 10:00 | Fabio Fognini v Andrey Rublev | 3-6,7-5,4-6,2-6 |
| Wimbledon | 2021/06/30 17:55 | Lloyd Harris v Andrey Rublev | 1-6,2-6,5-7 |
| Wimbledon | 2021/06/28 15:45 | Federico Delbonis v Andrey Rublev | 6-4,4-6,1-6,2-6 |
| ATP Halle | 2021/06/20 12:00 | Ugo Humbert v Andrey Rublev | 6-3,7-6 |
| ATP Halle | 2021/06/19 10:00 | Andrey Rublev v Nikoloz Basilashvili | 6-1,3-6,6-3 |
Away History
| ATP Toronto | 2021/08/11 15:00 | John Isner v Cristian Garin | 4-6,6-3,6-4 |
| ATP Toronto | 2021/08/10 17:25 | John Isner v Alejandro Davidovich Fokina | 6-4,6-1 |
| ATP Atlanta | 2021/08/01 21:00 | Brandon Nakashima v John Isner | 6-7,5-7 |
| ATP Atlanta | 2021/07/31 23:00 | Taylor Fritz v John Isner | 6-7,7-5,3-6 |
| ATP Atlanta | 2021/07/31 00:00 | John Isner v Christopher O'Connell | 7-6,6-7,6-4 |
| ATP Atlanta | 2021/07/29 23:00 | John Isner v Jack Sock | 7-6,6-4 |
| ATP Atlanta | 2021/07/27 19:00 | John Isner v Jeffrey John Wolf | 6-4,6-7,6-4 |
| ATP Los Cabos | 2021/07/24 03:00 | Brandon Nakashima v John Isner | 7-5,6-4 |