[77] Nebraska 20-23 Michigan State [22] 2021-09-25 23:00
Stadium: Spartan Stadium Round: 1
Home Manager: Melvin Tucker Away Manager: Scott Frost
Head to Head
| NCAAF | 2018/11/17 17:00 | Michigan State v Nebraska | W | 6-9 |
| NCAAF | 2015/11/08 00:00 | Nebraska v Michigan State | W | 39-38 |
| NCAAF | 2014/10/05 00:00 | Michigan State v Nebraska | L | 27-22 |
| NCAAF | 2012/11/03 12:00 | Michigan State v Nebraska | W | 24-28 |
| NCAAF | 2011/10/29 12:00 | Nebraska v Michigan State | W | 24-3 |
| NCAAF Bowl Games | 2003/12/29 12:00 | Michigan State v Nebraska | W | 3-17 |
Home History
| NCAAF | 2021/09/18 16:00 | Nebraska v Oklahoma | L | 16-23 |
| NCAAF | 2021/09/11 19:30 | Buffalo v Nebraska | W | 3-28 |
| NCAAF | 2021/09/04 16:00 | Fordham v Nebraska | W | 7-52 |
| NCAAF | 2021/08/28 17:00 | Nebraska v Illinois | L | 22-30 |
| NCAAF | 2020/12/19 00:30 | Nebraska v Rutgers | W | 28-21 |
| NCAAF | 2020/12/12 17:00 | Minnesota v Nebraska | L | 24-17 |
| NCAAF | 2020/12/05 17:00 | Nebraska v Purdue | W | 37-27 |
| NCAAF | 2020/11/27 18:00 | Nebraska v Iowa | L | 20-26 |
Away History
| NCAAF | 2021/09/18 16:00 | Michigan State v Miami Florida | W | 38-17 |
| NCAAF | 2021/09/11 16:00 | Youngstown State v Michigan State | W | 14-42 |
| NCAAF | 2021/09/04 01:00 | Michigan State v Northwestern | W | 38-21 |
| NCAAF | 2020/12/12 17:00 | Michigan State v Penn State | L | 24-39 |
| NCAAF | 2020/12/05 17:00 | Ohio State v Michigan State | L | 52-12 |
| NCAAF | 2020/11/28 20:30 | Northwestern v Michigan State | W | 20-29 |
| NCAAF | 2020/11/14 17:00 | Indiana v Michigan State | L | 24-0 |
| NCAAF | 2020/11/07 17:00 | Michigan State v Iowa | L | 7-49 |