[8] Michigan State 20-15 Indiana [95] 2021-10-16 16:00
Stadium: Memorial Stadium (Bloomington, IN) Round: 1
Home Manager: Tom Allen Away Manager: Melvin Tucker
Head to Head
| NCAAF | 2020/11/14 17:00 | Indiana v Michigan State | L | 24-0 |
| NCAAF | 2019/09/28 19:30 | Indiana v Michigan State | W | 31-40 |
| NCAAF | 2018/09/22 23:30 | Michigan State v Indiana | W | 35-21 |
| NCAAF | 2017/10/21 19:30 | Indiana v Michigan State | W | 9-17 |
| NCAAF | 2016/10/02 00:00 | Michigan State v Indiana | L | 21-24 |
| NCAAF | 2015/10/24 19:30 | Michigan State v Indiana | W | 52-26 |
| NCAAF | 2014/10/18 19:30 | Indiana v Michigan State | W | 17-56 |
| NCAAF | 2012/10/06 12:00 | Indiana v Michigan State | W | 27-31 |
Home History
| NCAAF | 2021/10/09 16:00 | Michigan State v Rutgers | W | 31-13 |
| NCAAF | 2021/10/02 23:30 | Western Kentucky v Michigan State | W | 31-48 |
| NCAAF | 2021/09/25 23:00 | Nebraska v Michigan State | W | 20-23 |
| NCAAF | 2021/09/18 16:00 | Michigan State v Miami Florida | W | 38-17 |
| NCAAF | 2021/09/11 16:00 | Youngstown State v Michigan State | W | 14-42 |
| NCAAF | 2021/09/04 01:00 | Michigan State v Northwestern | W | 38-21 |
| NCAAF | 2020/12/12 17:00 | Michigan State v Penn State | L | 24-39 |
| NCAAF | 2020/12/05 17:00 | Ohio State v Michigan State | L | 52-12 |
Away History
| NCAAF | 2021/10/02 23:30 | Indiana v Penn State | L | 0-24 |
| NCAAF | 2021/09/26 00:00 | Indiana v Western Kentucky | W | 33-31 |
| NCAAF | 2021/09/18 16:00 | Cincinnati v Indiana | L | 38-24 |
| NCAAF | 2021/09/11 23:30 | Idaho v Indiana | W | 14-56 |
| NCAAF | 2021/09/04 19:30 | Indiana v Iowa | L | 6-34 |
| NCAAF | 2021/01/02 17:30 | Mississippi v Indiana | L | 26-20 |
| NCAAF | 2020/12/05 20:30 | Indiana v Wisconsin | W | 14-6 |
| NCAAF | 2020/11/28 17:00 | Maryland v Indiana | W | 11-27 |