[57] Charleston Southern 28-31 East Carolina [102] 2021-09-25 22:00
Stadium: Bagwell Field at Dowdy-Ficklen Stadium Round: 1
Home Manager: Mike Houston Away Manager: Autry Denson
Home History
| NCAAF | 2021/09/18 22:00 | Monmouth v Charleston Southern | L | 41-14 |
| NCAAF | 2021/09/11 18:00 | Charleston Southern v The Citadel | W | 38-21 |
| NCAAF | 2021/04/17 16:00 | Gardner Webb v Charleston Southern | W | 7-20 |
| NCAAF | 2021/04/10 16:00 | Robert Morris v Charleston Southern | W | 14-27 |
| NCAAF | 2021/03/27 17:00 | Charleston Southern v Monmouth | L | 17-35 |
| NCAAF | 2021/03/13 18:00 | Charleston Southern v Kennesaw State | L | 19-24 |
| NCAAF | 2019/11/23 20:30 | Campbell v Charleston Southern | W | 31-41 |
| NCAAF | 2019/11/16 18:00 | Charleston Southern v Presbyterian | W | 27-7 |
Away History
| NCAAF | 2021/09/18 22:00 | East Carolina v Marshall | W | 42-38 |
| NCAAF | 2021/09/11 16:00 | South Carolina v East Carolina | L | 20-17 |
| NCAAF | 2021/09/02 23:30 | East Carolina v Appalachian St | L | 19-33 |
| NCAAF | 2020/11/28 17:00 | SMU v East Carolina | W | 38-52 |
| NCAAF | 2020/11/21 17:00 | East Carolina v Temple | W | 28-3 |
| NCAAF | 2020/11/14 00:30 | East Carolina v Cincinnati | L | 17-55 |
| NCAAF | 2020/11/07 17:00 | Tulane v East Carolina | L | 38-21 |
| NCAAF | 2020/10/31 01:00 | East Carolina v Tulsa | L | 30-34 |