[80] Indiana 0-24 Penn State [18] 2021-10-02 23:30
Stadium: Beaver Stadium Round: 1
Home Manager: James Franklin Away Manager: Tom Allen
Head to Head
| NCAAF | 2020/10/24 19:30 | Penn State v Indiana | W | 35-36 |
| NCAAF | 2019/11/16 17:00 | Indiana v Penn State | L | 27-34 |
| NCAAF | 2018/10/20 19:30 | Penn State v Indiana | L | 33-28 |
| NCAAF | 2017/09/30 19:30 | Indiana v Penn State | L | 14-45 |
| NCAAF | 2016/11/12 17:00 | Penn State v Indiana | L | 45-31 |
| NCAAF | 2015/10/10 16:00 | Penn State v Indiana | L | 29-7 |
| NCAAF | 2014/11/08 17:00 | Indiana v Penn State | L | 7-13 |
| NCAAF | 2012/11/17 12:00 | Penn State v Indiana | L | 45-22 |
Home History
| NCAAF | 2021/09/26 00:00 | Indiana v Western Kentucky | W | 33-31 |
| NCAAF | 2021/09/18 16:00 | Cincinnati v Indiana | L | 38-24 |
| NCAAF | 2021/09/11 23:30 | Idaho v Indiana | W | 14-56 |
| NCAAF | 2021/09/04 19:30 | Indiana v Iowa | L | 6-34 |
| NCAAF | 2021/01/02 17:30 | Mississippi v Indiana | L | 26-20 |
| NCAAF | 2020/12/05 20:30 | Indiana v Wisconsin | W | 14-6 |
| NCAAF | 2020/11/28 17:00 | Maryland v Indiana | W | 11-27 |
| NCAAF | 2020/11/21 17:00 | Indiana v Ohio State | L | 35-42 |
Away History
| NCAAF | 2021/09/25 16:00 | Villanova v Penn State | W | 17-38 |
| NCAAF | 2021/09/18 23:30 | Auburn v Penn State | W | 20-28 |
| NCAAF | 2021/09/11 19:30 | Ball State v Penn State | W | 13-44 |
| NCAAF | 2021/09/04 16:00 | Penn State v Wisconsin | W | 16-10 |
| NCAAF | 2020/12/19 22:30 | Illinois v Penn State | W | 21-56 |
| NCAAF | 2020/12/12 17:00 | Michigan State v Penn State | W | 24-39 |
| NCAAF | 2020/12/05 17:00 | Penn State v Rutgers | W | 23-7 |
| NCAAF | 2020/11/28 17:00 | Penn State v Michigan | W | 27-17 |