[13] Pittsburgh 41-34 Tennessee [27] 2021-09-11 16:00
Stadium: Neyland Stadium Round: 1
Home Manager: Josh Heupel Away Manager: Pat Narduzzi
Home History
| NCAAF | 2021/09/04 20:00 | Massachusetts v Pittsburgh | W | 7-51 |
| NCAAF | 2020/12/11 00:00 | Pittsburgh v Georgia Tech | W | 34-20 |
| NCAAF | 2020/11/28 20:30 | Pittsburgh v Clemson | L | 17-52 |
| NCAAF | 2020/11/21 21:00 | Virginia Tech v Pittsburgh | W | 14-47 |
| NCAAF | 2020/11/07 21:00 | Pittsburgh v Florida State | W | 41-17 |
| NCAAF | 2020/10/24 19:30 | Notre Dame v Pittsburgh | L | 45-3 |
| NCAAF | 2020/10/17 16:00 | Pittsburgh v Miami Florida | L | 19-31 |
| NCAAF | 2020/10/10 20:00 | Pittsburgh v Boston College | L | 30-31 |
Away History
| NCAAF | 2021/09/03 00:00 | Bowling Green v Tennessee | W | 6-38 |
| NCAAF | 2020/12/19 17:00 | Texas A&M v Tennessee | L | 34-13 |
| NCAAF | 2020/12/12 21:00 | Tennessee v Vanderbilt | W | 42-17 |
| NCAAF | 2020/12/05 20:30 | Florida v Tennessee | L | 31-19 |
| NCAAF | 2020/11/22 00:00 | Tennessee v Auburn | L | 17-30 |
| NCAAF | 2020/11/08 00:30 | Tennessee v Arkansas | L | 13-24 |
| NCAAF | 2020/10/24 19:30 | Alabama v Tennessee | L | 48-17 |
| NCAAF | 2020/10/17 16:00 | Kentucky v Tennessee | L | 34-7 |