[55] Iowa State 21-28 Oklahoma [11] 2021-11-20 17:00
Stadium: Gaylord Family Oklahoma Memorial Stadium Round: 1
Home Manager: Lincoln Riley Away Manager: Matt Campbell
Head to Head
| NCAAF | 2020/12/19 17:00 | Oklahoma v Iowa State | L | 27-21 |
| NCAAF | 2020/10/03 23:30 | Oklahoma v Iowa State | W | 30-37 |
| NCAAF | 2019/11/10 01:00 | Iowa State v Oklahoma | L | 41-42 |
| NCAAF | 2018/09/15 16:00 | Oklahoma v Iowa State | L | 37-27 |
| NCAAF | 2017/10/07 16:00 | Iowa State v Oklahoma | W | 38-31 |
| NCAAF | 2016/11/03 23:30 | Oklahoma v Iowa State | L | 34-24 |
| NCAAF | 2015/11/08 00:00 | Oklahoma v Iowa State | L | 52-16 |
| NCAAF | 2014/11/01 16:00 | Iowa State v Oklahoma | L | 14-59 |
Home History
| NCAAF | 2021/11/13 20:30 | Iowa State v Texas Tech | L | 38-41 |
| NCAAF | 2021/11/06 23:30 | Texas v Iowa State | W | 7-30 |
| NCAAF | 2021/10/30 18:00 | Iowa State v West Virginia | L | 31-38 |
| NCAAF | 2021/10/23 19:30 | Oklahoma State v Iowa State | W | 21-24 |
| NCAAF | 2021/10/16 23:30 | Iowa State v Kansas State | W | 33-20 |
| NCAAF | 2021/10/02 23:00 | Kansas v Iowa State | W | 7-59 |
| NCAAF | 2021/09/25 19:30 | Iowa State v Baylor | L | 29-31 |
| NCAAF | 2021/09/19 02:30 | Iowa State v UNLV | W | 48-3 |
Away History
| NCAAF | 2021/11/13 17:00 | Oklahoma v Baylor | L | 14-27 |
| NCAAF | 2021/10/30 19:30 | Texas Tech v Oklahoma | W | 21-52 |
| NCAAF | 2021/10/23 16:00 | Oklahoma v Kansas | W | 35-23 |
| NCAAF | 2021/10/16 23:30 | TCU v Oklahoma | W | 31-52 |
| NCAAF | 2021/10/09 16:00 | Oklahoma v Texas | W | 55-48 |
| NCAAF | 2021/10/02 19:30 | Oklahoma v Kansas State | W | 37-31 |
| NCAAF | 2021/09/25 23:30 | West Virginia v Oklahoma | W | 13-16 |
| NCAAF | 2021/09/18 16:00 | Nebraska v Oklahoma | W | 16-23 |