[17] Mississippi 20-31 Auburn [39] 2021-10-30 23:00
Stadium: Jordan-Hare Stadium Round: 1
Home Manager: Bryan Harsin Away Manager: Lane Kiffin
Head to Head
| NCAAF | 2020/10/24 16:00 | Auburn v Mississippi | L | 35-28 |
| NCAAF | 2019/11/02 23:00 | Mississippi v Auburn | L | 14-20 |
| NCAAF | 2018/10/20 16:00 | Auburn v Mississippi | L | 31-16 |
| NCAAF | 2017/10/07 16:00 | Mississippi v Auburn | L | 23-44 |
| NCAAF | 2016/10/29 23:15 | Auburn v Mississippi | L | 40-29 |
| NCAAF | 2015/10/31 16:00 | Auburn v Mississippi | W | 19-27 |
| NCAAF | 2014/11/01 23:00 | Mississippi v Auburn | L | 31-35 |
| NCAAF | 2012/10/13 12:00 | Mississippi v Auburn | W | 41-20 |
Home History
| NCAAF | 2021/10/23 19:30 | LSU v Mississippi | W | 17-31 |
| NCAAF | 2021/10/16 23:30 | Mississippi v Tennessee | W | 31-26 |
| NCAAF | 2021/10/09 16:00 | Arkansas v Mississippi | W | 51-52 |
| NCAAF | 2021/10/02 19:30 | Mississippi v Alabama | L | 21-42 |
| NCAAF | 2021/09/19 00:00 | Tulane v Mississippi | W | 21-61 |
| NCAAF | 2021/09/11 23:30 | Austin Peay v Mississippi | W | 17-54 |
| NCAAF | 2021/09/07 00:00 | Louisville v Mississippi | W | 24-43 |
| NCAAF | 2021/01/02 17:30 | Mississippi v Indiana | W | 26-20 |
Away History
| NCAAF | 2021/10/16 16:00 | Auburn v Arkansas | W | 38-23 |
| NCAAF | 2021/10/09 19:30 | Georgia v Auburn | L | 34-10 |
| NCAAF | 2021/10/03 01:00 | Auburn v LSU | W | 24-19 |
| NCAAF | 2021/09/25 20:00 | Georgia State v Auburn | W | 24-34 |
| NCAAF | 2021/09/18 23:30 | Auburn v Penn State | L | 20-28 |
| NCAAF | 2021/09/11 16:00 | Alabama State v Auburn | W | 0-62 |
| NCAAF | 2021/09/04 23:00 | Akron v Auburn | W | 10-60 |
| NCAAF | 2021/01/01 18:00 | Auburn v Northwestern | L | 19-35 |