[107] SE Missouri State 28-59 Missouri [60] 2021-09-18 16:00
Stadium: Memorial Stadium/Faurot Field Round: 1
Home Manager: Eliah Drinkwitz Away Manager: Tom Matukewicz
Head to Head
| NCAAF | 2019/09/14 23:30 | SE Missouri St v Missouri | L | 0-50 |
| NCAAF | 2015/09/05 20:00 | Missouri v SE Missouri St | L | 34-3 |
| NCAAF | 2008/09/06 12:00 | Missouri v SE Missouri St | L | 52-3 |
Home History
| NCAAF | 2021/09/11 23:00 | SE Missouri St v Sam Houston State | L | 14-52 |
| NCAAF | 2021/09/02 23:30 | SO Illinois v SE Missouri St | L | 47-21 |
| NCAAF | 2021/04/11 19:30 | SE Missouri St v Tennessee State | W | 46-23 |
| NCAAF | 2021/04/03 18:00 | SE Missouri St v Tennessee Martin | W | 21-16 |
| NCAAF | 2021/03/28 19:00 | Tennessee Tech v SE Missouri St | W | 21-24 |
| NCAAF | 2021/03/21 19:00 | SE Missouri St v Jacksonville State | L | 3-21 |
| NCAAF | 2021/03/14 19:00 | Austin Peay v SE Missouri St | L | 49-42 |
| NCAAF | 2021/03/07 20:00 | Murray State v SE Missouri St | L | 24-21 |
Away History
| NCAAF | 2021/09/11 23:30 | Missouri v Kentucky | L | 28-35 |
| NCAAF | 2021/09/04 20:00 | Central Michigan v Missouri | W | 24-34 |
| NCAAF | 2020/12/19 20:30 | Missouri v Mississippi State | L | 32-51 |
| NCAAF | 2020/12/12 17:00 | Georgia v Missouri | L | 49-14 |
| NCAAF | 2020/12/05 17:00 | Arkansas v Missouri | W | 48-50 |
| NCAAF | 2020/11/28 17:00 | Vanderbilt v Missouri | W | 0-41 |
| NCAAF | 2020/11/22 00:30 | Missouri v South Carolina | W | 17-10 |
| NCAAF | 2020/10/31 23:30 | Missouri v Florida | L | 17-41 |