[115] Kansas 7-59 Iowa State [74] 2021-10-02 23:00
Stadium: Jack Trice Stadium Round: 1
Home Manager: Matt Campbell Away Manager: Lance Leipold
Head to Head
| NCAAF | 2020/10/31 16:00 | Iowa State v Kansas | L | 52-22 |
| NCAAF | 2019/11/23 17:00 | Kansas v Iowa State | L | 31-41 |
| NCAAF | 2018/11/03 16:00 | Iowa State v Kansas | L | 27-3 |
| NCAAF | 2017/10/14 16:00 | Kansas v Iowa State | L | 0-45 |
| NCAAF | 2016/11/12 17:00 | Iowa State v Kansas | L | 31-24 |
| NCAAF | 2015/10/03 16:00 | Iowa State v Kansas | L | 38-13 |
| NCAAF | 2014/11/08 20:30 | Kansas v Iowa State | W | 34-14 |
| NCAAF | 2012/11/17 12:00 | Kansas v Iowa State | L | 23-51 |
Home History
| NCAAF | 2021/09/25 20:00 | Kansas v Duke | L | 33-52 |
| NCAAF | 2021/09/18 19:30 | Baylor v Kansas | L | 45-7 |
| NCAAF | 2021/09/10 23:30 | Kansas v Coastal Carolina | L | 22-49 |
| NCAAF | 2021/09/04 00:00 | South Dakota v Kansas | W | 14-17 |
| NCAAF | 2020/12/05 17:00 | Kansas v Texas Tech | L | 13-16 |
| NCAAF | 2020/11/29 01:00 | TCU v Kansas | L | 59-23 |
| NCAAF | 2020/11/07 20:30 | Kansas v Oklahoma | L | 9-62 |
| NCAAF | 2020/10/31 16:00 | Iowa State v Kansas | L | 52-22 |
Away History
| NCAAF | 2021/09/25 19:30 | Iowa State v Baylor | L | 29-31 |
| NCAAF | 2021/09/19 02:30 | Iowa State v UNLV | W | 48-3 |
| NCAAF | 2021/09/11 20:30 | Iowa v Iowa State | L | 27-17 |
| NCAAF | 2021/09/04 20:30 | Northern Iowa v Iowa State | W | 10-16 |
| NCAAF | 2021/01/02 21:00 | Oregon v Iowa State | W | 17-34 |
| NCAAF | 2020/12/19 17:00 | Oklahoma v Iowa State | L | 27-21 |
| NCAAF | 2020/12/05 20:30 | West Virginia v Iowa State | W | 6-42 |
| NCAAF | 2020/11/27 17:00 | Iowa State v Texas | W | 23-20 |