Stadium: Gate City Bank Field at the Fargodome Round: 1
Home Manager: Matt Entz Away Manager: Bobby Petrino
| NCAAF | 2021/03/06 20:00 | North Dakota State v Missouri St | L | 25-0 |
| NCAAF | 2019/10/19 19:30 | Missouri St v North Dakota State | L | 0-22 |
| NCAAF FCS | 2018/11/10 20:00 | North Dakota State v Missouri St | L | 48-7 |
| NCAAF | 2017/09/30 18:00 | North Dakota State v Missouri St | L | 38-11 |
| NCAAF | 2021/10/16 19:00 | Indiana State v Missouri St | W | 7-37 |
| NCAAF | 2021/10/09 18:00 | Missouri St v Youngstown State | L | 33-41 |
| NCAAF | 2021/10/02 18:00 | Missouri St v Illinois State | W | 41-20 |
| NCAAF | 2021/09/26 00:00 | South Dakota v Missouri St | W | 23-31 |
| NCAAF | 2021/09/12 00:00 | Central Arkansas v Missouri St | W | 34-43 |
| NCAAF | 2021/09/04 23:00 | Missouri St v Oklahoma State | L | 16-23 |
| NCAAF | 2021/04/24 20:00 | Missouri St v North Dakota | L | 10-44 |
| NCAAF | 2021/04/10 19:00 | Youngstown State v Missouri St | W | 10-21 |
| NCAAF | 2021/10/16 19:00 | North Dakota State v Illinois State | W | 20-0 |
| NCAAF | 2021/10/09 18:00 | Northern Iowa v North Dakota State | W | 20-34 |
| NCAAF | 2021/10/02 19:00 | North Dakota State v North Dakota | W | 16-10 |
| NCAAF | 2021/09/18 22:00 | North Dakota State v Towson | W | 35-7 |
| NCAAF | 2021/09/11 19:30 | Valparaiso v North Dakota State | W | 0-64 |
| NCAAF | 2021/09/04 19:30 | Albany v North Dakota State | W | 6-28 |
| NCAAF | 2021/05/02 19:00 | North Dakota State v Sam Houston State | L | 20-24 |
| NCAAF | 2021/04/24 19:30 | East Washington v North Dakota State | W | 20-42 |