Stadium: Tucker Stadium Round: 1
Home Manager: Dewayne Alexander Away Manager:
| NCAAF | 2021/10/16 19:00 | Tennessee Tech v Tennessee State | L | 13-20 |
| NCAAF | 2021/10/09 18:00 | Tennessee Tech v North Carolina Central | W | 27-16 |
| NCAAF | 2021/10/02 18:30 | SE Missouri St v Tennessee Tech | W | 17-28 |
| NCAAF | 2021/09/25 18:30 | Eastern Illinois v Tennessee Tech | L | 28-14 |
| NCAAF | 2021/09/18 16:00 | Tennessee Tech v Tennessee | L | 0-56 |
| NCAAF | 2021/09/11 18:30 | Furman v Tennessee Tech | L | 26-0 |
| NCAAF | 2021/09/02 23:00 | Tennessee Tech v Samford | L | 14-52 |
| NCAAF | 2021/04/11 20:00 | Tennessee Tech v Tennessee Martin | L | 7-40 |
| NCAAF | 2021/10/16 18:00 | Norfolk State v Lynchburg Dragons | L | 42-14 |
| NCAAF | 2021/10/09 18:00 | Delaware State v Lynchburg Dragons | L | 56-6 |
| NCAAF | 2021/10/02 18:00 | Erskine Flying Fleet v Lynchburg Dragons | L | 59-13 |
| NCAAF | 2021/09/25 17:00 | Duquesne v Lynchburg Dragons | L | 56-7 |
| NCAAF | 2021/09/18 22:00 | Virginia Union Panthers v Lynchburg Dragons | L | 49-7 |
| NCAAF | 2021/09/09 23:00 | Mars Hill Lions v Lynchburg Dragons | L | 50-14 |
| NCAAF | 2021/09/04 16:00 | Virginia Wise Highland Cavaliers v Lynchburg Dragons | L | 54-0 |
| NCAAF | 2019/11/16 18:00 | Morgan State v Lynchburg Dragons | L | 59-26 |