Stadium: Tucker Stadium Round: 1
Home Manager: Dewayne Alexander Away Manager: Adam Cushing
| NCAAF | 2021/03/21 18:00 | Tennessee Tech v Eastern Illinois | W | 20-28 |
| NCAAF | 2019/09/28 21:00 | Tennessee Tech v Eastern Illinois | L | 40-29 |
| NCAAF | 2018/09/29 23:00 | Eastern Illinois v Tennessee Tech | W | 52-38 |
| NCAAF | 2017/10/07 23:00 | Eastern Illinois v Tennessee Tech | W | 24-23 |
| NCAAF | 2021/09/18 23:00 | Illinois State v Eastern Illinois | L | 31-24 |
| NCAAF | 2021/09/11 17:00 | Eastern Illinois v Dayton | L | 10-17 |
| NCAAF | 2021/09/04 23:00 | Eastern Illinois v South Carolina | L | 0-46 |
| NCAAF | 2021/08/28 22:00 | Eastern Illinois v Indiana State | L | 21-26 |
| NCAAF | 2021/04/03 18:00 | Jacksonville State v Eastern Illinois | L | 44-23 |
| NCAAF | 2021/03/28 19:00 | Eastern Illinois v Murray State | L | 27-41 |
| NCAAF | 2021/03/21 18:00 | Tennessee Tech v Eastern Illinois | W | 20-28 |
| NCAAF | 2021/03/14 18:00 | Eastern Illinois v Tennessee State | L | 20-21 |
| NCAAF | 2021/09/18 16:00 | Tennessee Tech v Tennessee | L | 0-56 |
| NCAAF | 2021/09/11 18:30 | Furman v Tennessee Tech | L | 26-0 |
| NCAAF | 2021/09/02 23:00 | Tennessee Tech v Samford | L | 14-52 |
| NCAAF | 2021/04/11 20:00 | Tennessee Tech v Tennessee Martin | L | 7-40 |
| NCAAF | 2021/04/03 18:30 | Tennessee State v Tennessee Tech | W | 10-24 |
| NCAAF | 2021/03/28 19:00 | Tennessee Tech v SE Missouri St | L | 21-24 |
| NCAAF | 2021/03/21 18:00 | Tennessee Tech v Eastern Illinois | L | 20-28 |
| NCAAF | 2021/03/14 18:30 | Murray State v Tennessee Tech | L | 36-31 |