Stadium: Seibert Stadium Round: 1
Home Manager: Chris Hatcher Away Manager: Randy Sanders
| NCAAF | 2021/02/20 18:00 | Samford v East Tennessee State | W | 17-24 |
| NCAAF | 2019/10/26 17:00 | East Tennessee State v Samford | L | 17-24 |
| NCAAF FCS | 2018/11/17 18:00 | Samford v East Tennessee State | L | 38-27 |
| NCAAF | 2017/11/11 20:00 | Samford v East Tennessee State | L | 42-7 |
| NCAAF | 2021/09/18 23:30 | Delaware State v East Tennessee State | W | 6-38 |
| NCAAF | 2021/09/11 23:30 | East Tennessee State v Virginia Wise Highland Cavaliers | W | 45-14 |
| NCAAF | 2021/09/05 00:00 | East Tennessee State v Vanderbilt | W | 23-3 |
| NCAAF | 2021/04/10 22:00 | East Tennessee State v Mercer | L | 13-21 |
| NCAAF | 2021/04/03 17:30 | East Tennessee State v VMI | W | 24-20 |
| NCAAF | 2021/03/27 17:00 | Western Carolina v East Tennessee State | W | 17-24 |
| NCAAF | 2021/03/20 17:00 | East Tennessee State v The Citadel | W | 28-21 |
| NCAAF | 2021/03/13 18:00 | Furman v East Tennessee State | L | 17-13 |
| NCAAF | 2021/09/18 18:30 | Samford v Western Carolina | W | 42-37 |
| NCAAF | 2021/09/11 23:00 | Samford v Tennessee Martin | L | 27-33 |
| NCAAF | 2021/09/02 23:00 | Tennessee Tech v Samford | W | 14-52 |
| NCAAF | 2021/04/17 17:00 | Mercer v Samford | W | 20-44 |
| NCAAF | 2021/03/27 17:00 | Samford v The Citadel | W | 55-7 |
| NCAAF | 2021/03/20 17:00 | VMI v Samford | L | 38-37 |
| NCAAF | 2021/03/13 18:00 | Wofford v Samford | W | 31-37 |
| NCAAF | 2021/03/06 18:00 | Samford v Furman | L | 37-44 |