McNeese State 20-23 SE Louisiana 2021-10-30 23:00
Stadium: Strawberry Stadium Round: 1
Home Manager: Frank Scelfo Away Manager: Frank Wilson
Head to Head
| NCAAF | 2021/10/02 17:00 | SE Louisiana v McNeese State | L | 38-35 |
| NCAAF | 2021/03/07 00:00 | McNeese State v SE Louisiana | L | 20-25 |
| NCAAF | 2019/10/05 21:00 | SE Louisiana v McNeese State | W | 34-38 |
| NCAAF FCS | 2018/11/03 19:30 | McNeese State v SE Louisiana | L | 6-23 |
| NCAAF | 2017/11/04 23:00 | McNeese State v SE Louisiana | W | 13-3 |
Home History
| NCAAF | 2021/10/23 17:00 | Incarnate Word v McNeese State | W | 20-28 |
| NCAAF | 2021/10/16 20:00 | McNeese State v Northwestern State | W | 35-17 |
| NCAAF | 2021/10/02 17:00 | SE Louisiana v McNeese State | L | 38-35 |
| NCAAF | 2021/09/25 16:00 | McNeese State v Incarnate Word | L | 0-31 |
| NCAAF | 2021/09/18 23:00 | McNeese State v Southern | W | 31-24 |
| NCAAF | 2021/09/12 00:00 | McNeese State v LSU | L | 7-34 |
| NCAAF | 2021/09/04 17:00 | McNeese State v West Florida | L | 36-42 |
| NCAAF | 2021/04/10 21:00 | McNeese State v Sam Houston State | L | 13-27 |
Away History
| NCAAF | 2021/10/23 20:00 | SE Louisiana v Northwestern State | W | 51-14 |
| NCAAF | 2021/10/16 21:00 | Houston Christian v SE Louisiana | W | 24-61 |
| NCAAF | 2021/10/09 17:00 | SE Louisiana v Nicholls State | W | 58-48 |
| NCAAF | 2021/10/02 17:00 | SE Louisiana v McNeese State | W | 38-35 |
| NCAAF | 2021/09/18 16:00 | SE Louisiana v Central Connecticut | W | 56-10 |
| NCAAF | 2021/09/11 23:00 | SE Louisiana v Louisiana Tech | L | 42-45 |
| NCAAF | 2021/09/04 23:00 | SE Louisiana v North Alabama | W | 49-28 |
| NCAAF | 2021/04/17 17:00 | SE Louisiana v SO Illinois | L | 48-55 |