Stadium: Daytona Stadium Round: 1
Home Manager: Terry Sims Away Manager: Fred McNair
| NCAAF | 2021/10/30 23:00 | Alcorn State v Southern | L | 35-38 |
| NCAAF | 2021/10/24 00:00 | Alcorn State v Texas Southern Tigers | W | 44-27 |
| NCAAF | 2021/10/16 20:00 | Alcorn State v Mississippi Valley State | W | 24-12 |
| NCAAF | 2021/10/09 19:00 | Grambling State v Alcorn State | W | 20-24 |
| NCAAF | 2021/09/23 23:30 | Alcorn State v Arkansas Pine Bluff | W | 39-38 |
| NCAAF | 2021/09/19 00:00 | Alcorn State v South Alabama | L | 21-28 |
| NCAAF | 2021/09/11 23:00 | Northwestern State v Alcorn State | W | 10-13 |
| NCAAF | 2021/08/28 23:00 | Alcorn State v North Carolina Central | L | 14-23 |
| NCAAF | 2021/10/23 18:00 | Bethune Cookman v Jackson State | L | 12-42 |
| NCAAF | 2021/10/16 17:00 | Prairie View v Bethune Cookman | L | 35-29 |
| NCAAF | 2021/10/09 20:00 | Mississippi Valley State v Bethune Cookman | L | 20-14 |
| NCAAF | 2021/10/02 17:30 | Bethune Cookman v South Carolina State | L | 35-42 |
| NCAAF | 2021/09/25 22:00 | Bethune Cookman v Alabama State | L | 24-38 |
| NCAAF | 2021/09/16 23:30 | Alabama v Bethune Cookman | L | 30-27 |
| NCAAF | 2021/09/11 22:30 | Bethune Cookman v Central Florida | L | 14-63 |
| NCAAF | 2021/09/05 01:00 | Bethune Cookman v UTEP | L | 28-38 |