McNeese State 31-24 Southern 2021-09-18 23:00
Stadium: A.W. Mumford Stadium Round: 1
Home History
| NCAAF | 2021/09/12 00:00 | McNeese State v LSU | L | 7-34 |
| NCAAF | 2021/09/04 17:00 | McNeese State v West Florida | L | 36-42 |
| NCAAF | 2021/04/10 21:00 | McNeese State v Sam Houston State | L | 13-27 |
| NCAAF | 2021/04/03 17:00 | Nicholls State v McNeese State | W | 31-43 |
| NCAAF | 2021/03/20 21:00 | McNeese State v Northwestern State | W | 21-7 |
| NCAAF | 2021/03/13 18:00 | Lamar v McNeese State | L | 27-26 |
| NCAAF | 2021/03/07 00:00 | McNeese State v SE Louisiana | L | 20-25 |
| NCAAF | 2021/02/27 18:00 | Incarnate Word v McNeese State | L | 48-20 |
Away History
| NCAAF | 2021/09/11 23:00 | Southern v Miles Golden Bears | W | 41-24 |
| NCAAF | 2021/09/04 23:00 | Southern v Troy | L | 3-55 |
| NCAAF | 2021/04/17 18:30 | Grambling State v Southern | W | 7-49 |
| NCAAF | 2021/04/03 21:00 | Southern v Jackson State | W | 34-14 |
| NCAAF | 2021/03/21 00:30 | Southern v Texas Southern Tigers | W | 51-23 |
| NCAAF | 2021/03/06 19:30 | Arkansas Pine Bluff v Southern | L | 33-30 |
| NCAAF | 2021/02/27 00:00 | Southern v Alabama State | W | 24-21 |
| NCAAF | 2019/12/07 21:00 | Southern v Alcorn State | L | 24-39 |