Stadium: Jack Spinks Stadium Round: 1
Home Manager: Fred McNair Away Manager: Eric Dooley
| NCAAF | 2019/09/21 22:00 | Prairie View v Alcorn State | L | 41-45 |
| NCAAF | 2018/10/27 19:00 | Prairie View v Alcorn State | L | 13-27 |
| NCAAF | 2017/10/14 19:00 | Alcorn State v Prairie View | L | 34-21 |
| NCAAF | 2021/11/06 19:00 | Alabama State v Prairie View | W | 20-24 |
| NCAAF | 2021/10/23 23:00 | Prairie View v Southern | W | 48-21 |
| NCAAF | 2021/10/16 17:00 | Prairie View v Bethune Cookman | W | 35-29 |
| NCAAF | 2021/09/30 23:30 | Arkansas Pine Bluff v Prairie View | W | 17-27 |
| NCAAF | 2021/09/25 21:00 | Grambling State v Prairie View | W | 10-24 |
| NCAAF | 2021/09/18 23:00 | Houston Christian v Prairie View | W | 27-37 |
| NCAAF | 2021/09/12 00:00 | Prairie View v Incarnate Word | L | 9-40 |
| NCAAF | 2021/09/05 00:00 | Prairie View v Texas Southern Tigers | W | 40-17 |
| NCAAF | 2021/11/06 16:00 | Alcorn State v Bethune Cookman | L | 31-35 |
| NCAAF | 2021/10/30 23:00 | Alcorn State v Southern | L | 35-38 |
| NCAAF | 2021/10/24 00:00 | Alcorn State v Texas Southern Tigers | W | 44-27 |
| NCAAF | 2021/10/16 20:00 | Alcorn State v Mississippi Valley State | W | 24-12 |
| NCAAF | 2021/10/09 19:00 | Grambling State v Alcorn State | W | 20-24 |
| NCAAF | 2021/09/23 23:30 | Alcorn State v Arkansas Pine Bluff | W | 39-38 |
| NCAAF | 2021/09/19 00:00 | Alcorn State v South Alabama | L | 21-28 |
| NCAAF | 2021/09/11 23:00 | Northwestern State v Alcorn State | W | 10-13 |