[113] South Florida 17-41 SMU [11] 2021-10-02 20:00
Stadium: Gerald J. Ford Stadium Round: 1
Home Manager: Sonny Dykes Away Manager: Jeff Scott
Head to Head
| NCAAF | 2019/09/28 20:00 | SMU v South Florida | L | 48-21 |
| NCAAF | 2016/11/20 00:00 | South Florida v SMU | W | 35-27 |
| NCAAF | 2015/10/24 20:00 | South Florida v SMU | W | 38-14 |
| NCAAF | 2014/11/16 01:00 | SMU v South Florida | W | 13-14 |
Home History
| NCAAF | 2021/09/26 02:15 | South Florida v BYU | L | 27-35 |
| NCAAF | 2021/09/18 23:00 | Florida A&M v South Florida | W | 17-38 |
| NCAAF | 2021/09/11 17:00 | Florida v South Florida | L | 42-20 |
| NCAAF | 2021/09/02 23:30 | South Florida v NC State | L | 0-45 |
| NCAAF | 2020/11/27 20:30 | Central Florida v South Florida | L | 58-46 |
| NCAAF | 2020/11/14 20:30 | South Florida v Houston | L | 21-56 |
| NCAAF | 2020/11/07 17:00 | South Florida v Memphis | L | 33-34 |
| NCAAF | 2020/10/23 23:30 | Tulsa v South Florida | L | 42-13 |
Away History
| NCAAF | 2021/09/25 16:00 | SMU v TCU | W | 42-34 |
| NCAAF | 2021/09/18 19:30 | SMU v Louisiana Tech | W | 39-37 |
| NCAAF | 2021/09/11 23:00 | North Texas v SMU | W | 12-35 |
| NCAAF | 2021/09/04 23:00 | Abilene Christian v SMU | W | 9-56 |
| NCAAF | 2020/11/28 17:00 | SMU v East Carolina | L | 38-52 |
| NCAAF | 2020/11/15 00:00 | SMU v Tulsa | L | 24-28 |
| NCAAF | 2020/11/07 17:00 | SMU v Temple | W | 47-23 |
| NCAAF | 2020/10/31 23:30 | Navy v SMU | W | 37-51 |