[63] Northern Illinois 10-63 Michigan [18] 2021-09-18 16:00
Stadium: Michigan Stadium Round: 1
Home Manager: Jim Harbaugh Away Manager: Thomas Hammock
Home History
| NCAAF | 2021/09/11 17:30 | Wyoming v Northern Illinois | L | 50-43 |
| NCAAF | 2021/09/04 23:30 | Northern Illinois v Georgia Tech | W | 22-21 |
| NCAAF | 2020/12/12 17:00 | Northern Illinois v Eastern Michigan | L | 33-41 |
| NCAAF | 2020/12/05 17:00 | Toledo v Northern Illinois | L | 41-24 |
| NCAAF | 2020/11/28 17:00 | Northern Illinois v Western Michigan | L | 27-30 |
| NCAAF | 2020/11/19 00:00 | Northern Illinois v Ball State | L | 25-31 |
| NCAAF | 2020/11/12 01:00 | Central Michigan v Northern Illinois | L | 40-10 |
| NCAAF | 2020/11/05 00:00 | Buffalo v Northern Illinois | L | 49-30 |
Away History
| NCAAF | 2021/09/12 00:00 | Washington v Michigan | W | 10-31 |
| NCAAF | 2021/09/04 16:00 | Western Michigan v Michigan | W | 14-47 |
| NCAAF | 2020/11/28 17:00 | Penn State v Michigan | L | 27-17 |
| NCAAF | 2020/11/22 00:30 | Michigan v Rutgers | W | 48-42 |
| NCAAF | 2020/11/15 00:30 | Wisconsin v Michigan | L | 49-11 |
| NCAAF | 2020/11/07 17:00 | Michigan v Indiana | L | 21-38 |
| NCAAF | 2020/10/31 16:00 | Michigan State v Michigan | L | 27-24 |
| NCAAF | 2020/10/24 23:30 | Michigan v Minnesota | W | 49-24 |