[26] Mississippi 21-42 Alabama [5] 2021-10-02 19:30
Stadium: Bryant-Denny Stadium Round: 1
Home Manager: Nick Saban Away Manager: Lane Kiffin
Head to Head
| NCAAF | 2020/10/10 23:30 | Alabama v Mississippi | L | 63-48 |
| NCAAF | 2019/09/28 19:30 | Mississippi v Alabama | L | 31-59 |
| NCAAF | 2018/09/15 23:00 | Alabama v Mississippi | L | 62-7 |
| NCAAF | 2017/10/01 01:00 | Mississippi v Alabama | L | 3-66 |
| NCAAF | 2016/09/17 19:30 | Alabama v Mississippi | L | 48-43 |
| NCAAF | 2015/09/20 01:15 | Alabama v Mississippi | W | 37-43 |
| NCAAF | 2014/10/04 19:30 | Mississippi v Alabama | W | 23-17 |
| NCAAF | 2012/09/29 12:00 | Alabama v Mississippi | L | 33-14 |
Home History
| NCAAF | 2021/09/19 00:00 | Tulane v Mississippi | W | 21-61 |
| NCAAF | 2021/09/11 23:30 | Austin Peay v Mississippi | W | 17-54 |
| NCAAF | 2021/09/07 00:00 | Louisville v Mississippi | W | 24-43 |
| NCAAF | 2021/01/02 17:30 | Mississippi v Indiana | W | 26-20 |
| NCAAF | 2020/12/19 20:30 | Mississippi v LSU | L | 48-53 |
| NCAAF | 2020/11/28 21:00 | Mississippi State v Mississippi | W | 24-31 |
| NCAAF | 2020/11/15 00:30 | South Carolina v Mississippi | W | 42-59 |
| NCAAF | 2020/10/31 20:00 | Mississippi v Vanderbilt | W | 54-21 |
Away History
| NCAAF | 2021/10/02 19:00 | Alabama v Grambling State | L | 28-37 |
| NCAAF | 2021/09/25 23:30 | Southern Mississippi v Alabama | W | 14-63 |
| NCAAF | 2021/09/25 21:00 | Tuskegee v Alabama | W | 35-45 |
| NCAAF | 2021/09/18 19:30 | Alabama v Florida | W | 31-29 |
| NCAAF | 2021/09/16 23:30 | Alabama v Bethune Cookman | W | 30-27 |
| NCAAF | 2021/09/11 20:00 | Mercer v Alabama | W | 14-48 |
| NCAAF | 2021/09/04 23:00 | South Carolina State v Alabama | W | 41-42 |
| NCAAF | 2021/09/04 19:30 | Alabama v Miami Florida | W | 44-13 |