[11] South Carolina 20-17 East Carolina [103] 2021-09-11 16:00
Stadium: Bagwell Field at Dowdy-Ficklen Stadium Round: 1
Home Manager: Mike Houston Away Manager: Shane Beamer
Head to Head
| NCAAF | 2016/09/17 20:00 | South Carolina v East Carolina | W | 20-15 |
| NCAAF | 2014/09/06 23:00 | South Carolina v East Carolina | W | 33-23 |
| NCAAF | 2012/09/08 12:00 | South Carolina v East Carolina | W | 48-10 |
| NCAAF | 2011/09/03 12:00 | East Carolina v South Carolina | W | 37-56 |
Home History
| NCAAF | 2021/09/04 23:00 | Eastern Illinois v South Carolina | W | 0-46 |
| NCAAF | 2020/12/06 00:30 | South Carolina v Kentucky | L | 18-41 |
| NCAAF | 2020/11/29 00:30 | Georgia v South Carolina | L | 45-16 |
| NCAAF | 2020/11/22 00:30 | Missouri v South Carolina | L | 17-10 |
| NCAAF | 2020/11/15 00:30 | South Carolina v Mississippi | L | 42-59 |
| NCAAF | 2020/11/08 00:00 | Texas A&M v South Carolina | L | 48-3 |
| NCAAF | 2020/10/24 23:00 | South Carolina v LSU | L | 24-52 |
| NCAAF | 2020/10/17 16:00 | Auburn v South Carolina | W | 22-30 |
Away History
| NCAAF | 2021/09/02 23:30 | East Carolina v Appalachian St | L | 19-33 |
| NCAAF | 2020/11/28 17:00 | SMU v East Carolina | W | 38-52 |
| NCAAF | 2020/11/21 17:00 | East Carolina v Temple | W | 28-3 |
| NCAAF | 2020/11/14 00:30 | East Carolina v Cincinnati | L | 17-55 |
| NCAAF | 2020/11/07 17:00 | Tulane v East Carolina | L | 38-21 |
| NCAAF | 2020/10/31 01:00 | East Carolina v Tulsa | L | 30-34 |
| NCAAF | 2020/10/17 16:00 | Navy v East Carolina | L | 27-23 |
| NCAAF | 2020/10/10 23:00 | East Carolina v South Florida | W | 44-24 |