[2] Cincinnati 35-13 East Carolina [42] 2021-11-26 20:30
Stadium: Bagwell Field at Dowdy-Ficklen Stadium Round: 1
Home Manager: Mike Houston Away Manager: Luke Fickell
Head to Head
| NCAAF | 2020/11/14 00:30 | East Carolina v Cincinnati | W | 17-55 |
| NCAAF | 2019/11/02 23:00 | Cincinnati v East Carolina | W | 46-43 |
| NCAAF | 2018/11/23 20:30 | East Carolina v Cincinnati | W | 6-56 |
| NCAAF | 2017/11/18 17:00 | Cincinnati v East Carolina | L | 20-48 |
| NCAAF | 2016/10/22 23:00 | East Carolina v Cincinnati | W | 19-31 |
| NCAAF | 2015/11/28 17:00 | East Carolina v Cincinnati | W | 16-19 |
| NCAAF | 2014/11/14 00:00 | Cincinnati v East Carolina | W | 54-46 |
| NCAAF | 2004/09/25 12:00 | East Carolina v Cincinnati | W | 19-24 |
Home History
| NCAAF | 2021/11/20 20:30 | SMU v Cincinnati | W | 14-48 |
| NCAAF | 2021/11/12 23:00 | Cincinnati v South Florida | W | 45-28 |
| NCAAF | 2021/11/06 19:30 | Tulsa v Cincinnati | W | 20-28 |
| NCAAF | 2021/10/30 16:00 | Cincinnati v Tulane | W | 31-12 |
| NCAAF | 2021/10/23 16:00 | Cincinnati v Navy | W | 27-20 |
| NCAAF | 2021/10/16 16:00 | Central Florida v Cincinnati | W | 21-56 |
| NCAAF | 2021/10/08 23:00 | Temple v Cincinnati | W | 3-52 |
| NCAAF | 2021/10/02 18:30 | Cincinnati v Notre Dame | W | 24-13 |
Away History
| NCAAF | 2021/11/20 20:30 | East Carolina v Navy | W | 38-35 |
| NCAAF | 2021/11/13 17:00 | East Carolina v Memphis | W | 30-29 |
| NCAAF | 2021/11/06 19:00 | Temple v East Carolina | W | 3-45 |
| NCAAF | 2021/10/28 23:30 | South Florida v East Carolina | W | 14-29 |
| NCAAF | 2021/10/24 01:20 | East Carolina v Houston | L | 24-31 |
| NCAAF | 2021/10/09 22:00 | East Carolina v Central Florida | L | 16-20 |
| NCAAF | 2021/10/02 19:30 | Tulane v East Carolina | W | 29-52 |
| NCAAF | 2021/09/25 22:00 | Charleston Southern v East Carolina | W | 28-31 |