[15] Michigan 21-17 Penn State [31] 2021-11-13 17:00
Stadium: Beaver Stadium Round: 1
Home Manager: James Franklin Away Manager: Jim Harbaugh
Head to Head
| NCAAF | 2020/11/28 17:00 | Penn State v Michigan | L | 27-17 |
| NCAAF | 2019/10/19 23:30 | Michigan v Penn State | L | 21-28 |
| NCAAF | 2018/11/03 19:45 | Penn State v Michigan | W | 7-42 |
| NCAAF | 2017/10/21 23:30 | Michigan v Penn State | L | 13-42 |
| NCAAF | 2016/09/24 19:30 | Penn State v Michigan | W | 10-49 |
| NCAAF | 2015/11/21 17:00 | Penn State v Michigan | W | 16-28 |
| NCAAF | 2014/10/11 23:00 | Michigan v Penn State | W | 18-13 |
| NCAAF | 2010/10/30 12:00 | Penn State v Michigan | L | 41-31 |
Home History
| NCAAF | 2021/11/06 23:30 | Indiana v Michigan | W | 7-29 |
| NCAAF | 2021/10/30 16:00 | Michigan v Michigan State | L | 33-37 |
| NCAAF | 2021/10/23 16:00 | Northwestern v Michigan | W | 7-33 |
| NCAAF | 2021/10/09 23:30 | Michigan v Nebraska | W | 32-29 |
| NCAAF | 2021/10/02 16:00 | Michigan v Wisconsin | W | 38-17 |
| NCAAF | 2021/09/25 19:30 | Rutgers v Michigan | W | 13-20 |
| NCAAF | 2021/09/18 16:00 | Northern Illinois v Michigan | W | 10-63 |
| NCAAF | 2021/09/12 00:00 | Washington v Michigan | W | 10-31 |
Away History
| NCAAF | 2021/11/06 19:30 | Penn State v Maryland | W | 31-14 |
| NCAAF | 2021/10/30 23:30 | Penn State v Ohio State | L | 24-33 |
| NCAAF | 2021/10/23 16:00 | Illinois v Penn State | L | 20-18 |
| NCAAF | 2021/10/09 20:00 | Penn State v Iowa | L | 20-23 |
| NCAAF | 2021/10/02 23:30 | Indiana v Penn State | W | 0-24 |
| NCAAF | 2021/09/25 16:00 | Villanova v Penn State | W | 17-38 |
| NCAAF | 2021/09/18 23:30 | Auburn v Penn State | W | 20-28 |
| NCAAF | 2021/09/11 19:30 | Ball State v Penn State | W | 13-44 |