[2] Cincinnati 45-28 South Florida [115] 2021-11-12 23:00
Stadium: Raymond James Stadium Round: 1
Home Manager: Jeff Scott Away Manager: Luke Fickell
Head to Head
| NCAAF | 2020/10/03 19:30 | South Florida v Cincinnati | W | 7-28 |
| NCAAF | 2019/11/17 00:00 | Cincinnati v South Florida | W | 20-17 |
| NCAAF | 2018/11/11 00:00 | South Florida v Cincinnati | W | 23-35 |
| NCAAF | 2017/10/14 23:30 | Cincinnati v South Florida | L | 3-33 |
| NCAAF | 2016/10/01 23:00 | South Florida v Cincinnati | L | 45-20 |
| NCAAF | 2015/11/21 01:00 | South Florida v Cincinnati | L | 65-27 |
| NCAAF | 2014/10/24 23:00 | Cincinnati v South Florida | W | 34-17 |
| NCAAF | 2012/11/23 12:00 | Cincinnati v South Florida | W | 27-10 |
Home History
| NCAAF | 2021/11/06 19:30 | Tulsa v Cincinnati | W | 20-28 |
| NCAAF | 2021/10/30 16:00 | Cincinnati v Tulane | W | 31-12 |
| NCAAF | 2021/10/23 16:00 | Cincinnati v Navy | W | 27-20 |
| NCAAF | 2021/10/16 16:00 | Central Florida v Cincinnati | W | 21-56 |
| NCAAF | 2021/10/08 23:00 | Temple v Cincinnati | W | 3-52 |
| NCAAF | 2021/10/02 18:30 | Cincinnati v Notre Dame | W | 24-13 |
| NCAAF | 2021/09/18 16:00 | Cincinnati v Indiana | W | 38-24 |
| NCAAF | 2021/09/11 19:30 | Murray State v Cincinnati | W | 7-42 |
Away History
| NCAAF | 2021/11/06 23:30 | Houston v South Florida | L | 54-42 |
| NCAAF | 2021/10/28 23:30 | South Florida v East Carolina | L | 14-29 |
| NCAAF | 2021/10/23 23:00 | Temple v South Florida | W | 14-34 |
| NCAAF | 2021/10/16 16:00 | Tulsa v South Florida | L | 32-31 |
| NCAAF | 2021/10/02 20:00 | South Florida v SMU | L | 17-41 |
| NCAAF | 2021/09/26 02:15 | South Florida v BYU | L | 27-35 |
| NCAAF | 2021/09/18 23:00 | Florida A&M v South Florida | W | 17-38 |
| NCAAF | 2021/09/11 17:00 | Florida v South Florida | L | 42-20 |